ArticleChinese journal of integrative medicine2020
Inhibitory Mechanisms of Water Extract of Oplopanax elatus on Lipopolysaccharide-Induced Inflammatory Responses in RAW 264.7 Murine Macrophage Cells.
Article in Chinese journal of integrative medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 6 citations in OpenAlex.
- The effect and mechanism ofJournal of orthopaedic translation · 2021Article
- Falcarindiol and dichloromethane fraction are bioactive components inJournal of applied biomedicine · 2021Article
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7 authors at 1 institution in 1 country.
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Abstract
objectiveTo study the anti-inflammatory action and cellular mechanism of Oplopanax elatus.
methodsA hot water extract of OE (WOE) was prepared and a major constituent, syringin, was successfully isolated. Its content in WOE was found to be 214.0 µg/g dried plant (w/w). Their anti-inflammatory activities were examined using RAW 264.7 macrophages and a mouse model of croton oil-induced ear edema.
resultsIn lipopolysaccharide (LPS)-treated RAW 264.7 cells, a mouse macrophage cell line, WOE was found to significantly and strongly inhibit cyclooxygenase-2 (COX-2)-induced prostaglandin E
conclusionWater extract of OE exhibited multiple anti-inflammatory action mechanisms and may have potential for treating inflammatory disorders.
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