Evidence map›Paper›PMID 31970309›Full record

ReviewInternational journal of reproductive biomedicine2019

The role of melatonin in polycystic ovary syndrome: A review.

Sina Mojaverrostami, Narjes Asghari, Mahsa Khamisabadi, Heidar Heidari Khoei

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of reproductive biomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 39 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05298657 unknown statusnot on this mapstarted 2022, after this paper: background citation

The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment

Typeobservational_patient_registrySponsorFatima College of Health SciencesRan2022 to 2024Enrolled200ConditionsPoor Response to Ovulation Induction, PCOS, Endometriosis, Infertility, Female
NCT06551285 narecruitingnot on this mapstarted 2024, after this paper: background citation

Study of the Effect of a Nutritional Supplement on Microbiota, Metabolic Control, Inflammatory Profile, and Quality of Life in Patients With Polycystic Ovary Syndrome

TypeinterventionalSponsorCelia BañulsRan2024 to 2029Enrolled120ConditionsPolycystic Ovary Syndrome, Metabolic SyndromeArmsOvapro (Lifepro)
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  18. The Menstrual Cycle and Sleep.Sleep medicine clinics · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Sina MojaverrostamiDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Narjes AsghariDepartment of Molecular Medicine, Faculty of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Mahsa KhamisabadiFaculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Heidar Heidari KhoeiStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
National Institute of Genetic Engineering and Biotechnology · IRShahid Beheshti University of Medical Sciences · IRTehran University of Medical Sciences · IRUrmia University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolycystic ovary syndrome (PCOS) is a widespread endocrine disorder, affecting approximately 20% of women within reproductive age. It is associated with hyperandrogenism, obesity, menstrual irregularity, and anovulatory infertility. Melatonin is the main pineal gland hormone involved in the regulation of the circadian rhythm. In recent years, it has been observed that a reduction in melatonin levels of follicular fluid exists in PCOS patients. Melatonin receptors in the ovary and intra-follicular fluid adjust sex steroid secretion at different phases of ovarian follicular maturation. Moreover, melatonin is a strong antioxidant and an effective free radical scavenger, which protects ovarian follicles during follicular maturation.

objectiveIn this paper, we conducted a literature review and the summary of the current research on the role of melatonin in PCOS. MATERIALS AND

methodsElectronic databases including PubMed/MEDLINE, Web of Science, Scopus, and Reaxys were searched from their inception to October 2018 using the keywords "Melatonin" AND "Polycystic ovary syndrome" OR "PCOS."

resultsBased on the data included in our review, it was found that the administration of melatonin can improve the oocyte and embryo quality in PCOS patients. It may also have beneficial effects in correcting the hormonal alterations in PCOS patients.

conclusionSince metabolic dysfunction is the major finding contributing to the initiation of PCOS, melatonin can hinder this process via its improving effects on metabolic functions.

Indexed as

HyperandrogenismInfertilityMelatoninPCOS.

Identifiers

PMID31970309
PMCPMC6943797
OpenAlexW2995210491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.