Evidence map›Paper›PMID 31970205›Full record

ReviewMovement disorders clinical practice2020

Falls in Progressive Supranuclear Palsy.

Fraser S Brown, James B Rowe, Luca Passamonti, Timothy Rittman

Open access · hybridAbstract readReview
In one paragraph

Review in Movement disorders clinical practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  5. Dynamic Stability Analysis of Progressive Supranuclear Palsy Affected Gait Using Lyapunov Floquet Theory.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Fraser S BrownDepartment of Clinical Neurosciences Cambridge University Hospitals Cambridge United Kingdom.ORCID https://orcid.org/0000-0002-8314-4936
James B RoweDepartment of Clinical Neurosciences University of Cambridge Cambridge United Kingdom.ORCID https://orcid.org/0000-0001-7216-8679
Luca PassamontiDepartment of Clinical Neurosciences University of Cambridge Cambridge United Kingdom.
Timothy RittmanDepartment of Clinical Neurosciences University of Cambridge Cambridge United Kingdom.ORCID https://orcid.org/0000-0003-1063-6937
University of Cambridge · GB

Funding

Medical Research Council G1100464Medical Research Council MR/P01271X/1
6 · The paper itself

Abstract

backgroundDespite falls being an almost universal clinical feature and central to the presentation and diagnostic criteria of progressive supranuclear palsy, our understanding of falls is surprisingly limited and there are few effective treatment options.

objectivesTo provide an overview of the topic of the impact, assessment, mechanism, and management of falls in progressive supranuclear palsy.

methodsWe performed a literature search for "falls" and "progressive supranuclear palsy" and included additional relevant literature known to us. We synthesized this literature with experience from clinical practice.

resultsWe review current understanding of the pathophysiology of falls, highlighting the roles of the indirect pathway and the pedunculopontine nucleus. We go on to identify shortcomings in commonly used assessments to measure falls. We discuss medical and nonmedical fall prevention strategies, and finally we discuss balancing falls risk against promoting independence.

conclusionFalls are central to progressive supranuclear palsy presentation and diagnosis. Indirect locomotor and pedunculopontine nucleus dysfunction are thought to be the neural substrate of falls in this condition. Attempts to measure and prevent falls, by medical and nonmedical means, are currently limited. A personalized approach is advocated in the management of falls.

Indexed as

Fallsprogressive supranuclear palsy

Identifiers

PMID31970205
PMCPMC6962663
OpenAlexW2991622329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.