Evidence map›Paper›PMID 31970172›Full record

ArticleWorld journal of clinical cases2020

Relationship between β-amyloid protein 1-42, thyroid hormone levels and the risk of cognitive impairment after ischemic stroke.

Lei Mao, Xiao-Han Chen, Jian-Hua Zhuang, Peng Li, Yi-Xin Xu, Yu-Chen Zhao, Yue-Jin Ma, Bin He, You Yin

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of clinical cases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 5 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 5 syntheses or guidelines pooled it, 14 citations in OpenAlex.

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  6. Article
  7. Blood-Based Biomarkers for Post-Stroke Cognitive Impairment.Current issues in molecular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lei MaoDepartment of Neurology, Changzheng Hospital, the PLA Naval Medical University, Shanghai 200003, China.
Xiao-Han ChenDepartment of Neurology, Changzheng Hospital, the PLA Naval Medical University, Shanghai 200003, China.
Jian-Hua ZhuangDepartment of Neurology, Changzheng Hospital, the PLA Naval Medical University, Shanghai 200003, China.
Peng LiDepartment of Neurology, Changzheng Hospital, the PLA Naval Medical University, Shanghai 200003, China.
Yi-Xin XuDepartment of Neurology, Changzheng Hospital, the PLA Naval Medical University, Shanghai 200003, China.
Yu-Chen ZhaoDepartment of Neurology, Changzheng Hospital, the PLA Naval Medical University, Shanghai 200003, China.
Yue-Jin MaDepartment of Neurology, Changzheng Hospital, the PLA Naval Medical University, Shanghai 200003, China.
Bin HeDepartment of Neurology, Changzheng Hospital, the PLA Naval Medical University, Shanghai 200003, China.
You YinDepartment of Neurology, Changzheng Hospital, the PLA Naval Medical University, Shanghai 200003, China. yinyou179@163.com.
Shanghai Changzheng Hospital · CNShanghai First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-stroke cognitive impairment (PSCI) is not only a common consequence of stroke but also an important factor for adverse prognosis of patients. Biochemical indicators such as blood lipids and blood pressure are affected by many factors, and the ability of evaluating the progress of patients with PSCI is insufficient. Therefore, it is necessary to find sensitive markers for predicting the progress of patients and avoiding PSCI. Recent studies have shown that β-amyloid protein 1-42 (Aβ1-42) and thyroid hormone levels are closely related to PSCI, which may be the influencing factors of PSCI, but there are few related studies.

aimTo investigate the relationship between serum levels of Aβ and thyroid hormones in acute stage and PSCI and its predicted value.

methodsA total of 195 patients with acute cerebral infarction confirmed from June 2016 to January 2018 were enrolled in this study. Baseline data and serological indicators were recorded to assess cognitive function of patients. All patients were followed up for 1 year. Their cognitive functions were evaluated within 1 wk, 3 mo, 6 mo and 1 yr after stroke. At the end of follow-up, the patients were divided into PSCI and non-PSCI according to Montreal cognitive assessment score, and the relationship between biochemical indexes and the progression of PSCI was explored.

resultsCompared with patients with non-PSCI, the levels of Aβ1-42, triiodothyronine (T

conclusionAβ1-42 and T3 have the ability to predict the progression of PSCI, which is expected to be applied clinically to reduce the incidence of PSCI and improve the quality of life of patients.

Indexed as

Free thyroxinMontreal cognitive assessmentPost-stroke cognitive impairmentPrognosisTriiodothyronineβ-amyloid protein

Identifiers

PMID31970172
PMCPMC6962069
OpenAlexW2997724770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.