Evidence map›Paper›PMID 31970141›Full record

ArticleProstate international2019

The molecular targets of diclofenac differs from ibuprofen to induce apoptosis and epithelial mesenchymal transition due to alternation on oxidative stress management p53 independently in PC3 prostate cancer cells.

Elif D Arisan, Remzi O Akar, Ozge Rencuzogullari, Pinar Obakan Yerlikaya, Ajda Coker Gurkan, Beyza Akın, Elif Dener, Ecem Kayhan, Narcin Palavan Unsal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prostate international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Elif D ArisanIstanbul Kültür University, Department of Molecular Biology and Genetics, Atakoy Campus, 34156, Istanbul.
Remzi O AkarIstanbul Kültür University, Department of Molecular Biology and Genetics, Atakoy Campus, 34156, Istanbul.
Ozge RencuzogullariIstanbul Kültür University, Department of Molecular Biology and Genetics, Atakoy Campus, 34156, Istanbul.
Pinar Obakan YerlikayaIstanbul Kültür University, Department of Molecular Biology and Genetics, Atakoy Campus, 34156, Istanbul.
Ajda Coker GurkanIstanbul Kültür University, Department of Molecular Biology and Genetics, Atakoy Campus, 34156, Istanbul.
Beyza AkınIstanbul Kültür University, Department of Molecular Biology and Genetics, Atakoy Campus, 34156, Istanbul.
Elif DenerIstanbul Kültür University, Department of Molecular Biology and Genetics, Atakoy Campus, 34156, Istanbul.
Ecem KayhanIstanbul Kültür University, Department of Molecular Biology and Genetics, Atakoy Campus, 34156, Istanbul.
Narcin Palavan UnsalIstanbul Kültür University, Department of Molecular Biology and Genetics, Atakoy Campus, 34156, Istanbul.
Istanbul Kültür University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate cancer is the most common type of cancer among men. Studies showed that the regular use of nonsteroidal antiinflammatory drugs might reduce disease progression risk for prostate cancer patients with prostate cancer. We evaluated the effects of ectopic expression of p53 on the biological functions of ibuprofen and diclofenac. MATERIALS AND

methodsFor this purpose, We investigated cell death decision pathways related to survival and aggressive cellular phenotypes such as extrinsic/intrinsic apoptosis decision, Protein Kinase B/ Forkhead box O (AKT/FoxO) axis, mitogen-activated protein kinases (MAPKs), reactive oxygen species (ROS) generation, and EMT (epithelial mesenchymal transition) in wild type and p53 + PC3 prostate cancer cells. RESULTS AND

conclusionsIbuprofen (1 mM) and diclofenac (250 μM) effectively induced cell cycle arrest and led to apoptosis

Indexed as

ApoptosisDiclofenacEpithelial mesenchymal transitionIbuprofenNonsteroidal antiinflammatory drugsProstate cancerReactive oxygen species

Identifiers

PMID31970141
PMCPMC6962753
OpenAlexW2985567144

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.