ArticleAmerican journal of cardiovascular disease2019
Sarcopenia in heart failure with reduced ejection fraction.
Article in American journal of cardiovascular disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- People with heart failure, sarcopenia and chagas disease: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- Comparison of sarcopenia prevalence and prognostic features between HFrEF and HFpEF: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Sarcopenia and cardiovascular diseases: A systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Sarcopenia in heart failure: a systematic review and meta-analysis.ESC heart failure · 2021Pooled it
- Prevalence of sarcopenia in heart failure: A systematic review.Indian heart journalPooled it
- Trial
- Trial
- Biomarkers and the quadriceps femoris muscle architecture assessed by ultrasound in older adults with heart failure with preserved ejection fraction: a cross-sectional study.Aging clinical and experimental research · 2022Trial
- Changes in Physical Activity Following Heart Failure in Humans and Animal Models: A Scoping Review.Current heart failure reports · 2026Review
- Application and evidence gaps of sarcopenia diagnostic criteria in patients with heart failure: a scoping review.Frontiers in medicine · 2026Review
- Different Pattern in Circulating MicroRNA-22-3p Levels Between Patients With Primary Versus Secondary Sarcopenia.Aging cell · 2025Article
- Causal influence of muscle weakness on cardiometabolic diseases and osteoporosis.Scientific reports · 2023Article
- Bioinformatics and Systems Biology Approach to Identify the Pathogenetic Link between Heart Failure and Sarcopenia.Arquivos brasileiros de cardiologia · 2023Article
- Frailty alone and interactively with obesity predicts heart failure: Kuopio Ischaemic Heart Disease Risk Factor Study.ESC heart failure · 2023Article
- Sarcopenia and Cardiovascular Diseases.Circulation · 2023Review
- Correlation between frailty and cardiac structure and function in echocardiography in elderly patients with normal ejection fraction.Aging clinical and experimental research · 2023Article
- Article
- Sarcopenia: Inflammatory and Humoral Markers in Older Heart Failure Patients.Arquivos brasileiros de cardiologia · 2023Article
- Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study.Frontiers in cardiovascular medicine · 2022Article
- Malnutrition, Family Support, and Possible Sarcopenia in Patients Undergoing Transcatheter Aortic Valve Implantation.The Journal of cardiovascular nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate the prevalence of pre-sarcopenia and sarcopenia and their relationship with clinical variables, physical activity, quality of life, and diet in patients with heart failure with reduced left ventricular ejection fraction (HFrEF).
methodsWe performed a cross-sectional study in patients with HFrEF and matched controls. Clinical, laboratory analysis, dual-emission X-ray densitometry, handgrip strength, and physical activity level questionnaire assessments were performed. Echocardiography, quality of life, gait speed, and 24-hour nutritional recall questionnaire were also analyzed. Pre-sarcopenia and sarcopenia were defined according to the European Working Group on Sarcopenia in Older People with the cut-off points of the Foundation for the National Institute of Health.
results79 patients and 143 controls were enrolled. Pre-sarcopenia was found in 30.4%, and sarcopenia in 10.1% of the patients. Pre-sarcopenic patients were older and shorter, and had more fractures, higher calcemia, and creatinine (
conclusionPre-sarcopenia and sarcopenia were associated with aging. Despite having higher lean mass, women with HFrEF were weaker. Low gait speed was associated with biventricular systolic dysfunction.
Indexed as
Identifiers
31970027PMC6971421W3006538010What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.