ArticleInternational journal of hypertension2020
Association of Lactate Dehydrogenase with In-Hospital Mortality in Patients with Acute Aortic Dissection: A Retrospective Observational Study.
Article in International journal of hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 25 citations in OpenAlex.
- Prognostic value of endothelial activation and stress index (EASIX) on short-term and long-term outcomes in type B aortic dissection after thoracic endovascular repair: An observational study.JTCVS structural and endovascular · 2026Article
- Predictive value of initial triage vital signs for in-hospital mortality in acute aortic dissection patients: a retrospective study in the emergency department.Frontiers in medicine · 2026Article
- Predictive value of the combined evaluation of the neutrophil-to-lymphocyte ratio and lactate dehydrogenase level for coronary artery lesions in patients with acute Kawasaki disease.Italian journal of pediatrics · 2025Article
- Malperfusion in Acute Type A Aortic Dissection: Development of a Predictive Diagnostic Model.Current medical science · 2025Article
- Preoperative Hyperlactatemia Predicts Mortality in Acute Stanford Type A Dissection: A 16-Year-Period, Single-Center, Retrospective Study.Journal of clinical medicine · 2025Article
- Exploring the Cardiovascular Benefits of Extra Virgin Olive Oil: Insights into Mechanisms and Therapeutic Potential.Biomolecules · 2025Review
- Association Between Lactate Dehydrogenase/Albumin Ratio and in-Hospital Mortality in Patients with Acute Aortic Dissection.Journal of inflammation research · 2025Article
- Positive association between serum lactate dehydrogenase levels and blood pressure: evidence from NHANES 2015-2016.Frontiers in cardiovascular medicine · 2025Article
- Lactate dehydrogenase is an indicator for outcomes of short-term and long-term in septic patients.PloS one · 2025Article
- α-HBDH is a superior to LDH in predicting major adverse cardiovascular events in patients with acute aortic dissection.Heliyon · 2024Article
- Unleashing the Potential of Nrf2: A Novel Therapeutic Target for Pulmonary Vascular Remodeling.Antioxidants (Basel, Switzerland) · 2023Review
- A prediction model to predict in-hospital mortality in patients with acute type B aortic dissection.BMC cardiovascular disorders · 2023Article
- Diagnostic Value of Serum Lactate Dehydrogenase Level Measured in the Emergency Department in Predicting Clinical Outcome in Out-of-Hospital Cardiac Arrest: A Multicenter, Observational Study.Journal of clinical medicine · 2023Article
- Lactate dehydrogenase is associated with flow-mediated dilation in hypertensive patients.Scientific reports · 2023Article
- Impact of lactate dehydrogenase on prognosis of patients undergoing cardiac surgery.BMC cardiovascular disorders · 2022Article
- Risk factors for 30-day mortality in patients who received DeBakey type I aortic dissection repair surgery.Journal of cardiothoracic surgery · 2021Article
- Serum sodium on admission affects postoperative in-hospital mortality in acute aortic dissection patients.PloS one · 2021Observational
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence regarding the relationship between serum lactate dehydrogenase (LDH) levels and in-hospital mortality in acute aortic dissection (AAD) patients is extremely limited. We aimed to investigate the relationship between LDH and in-hospital mortality in AAD patients.
methodsThe present study was a retrospective observational study. A total of 1526 participants with acute aortic dissection were involved in a hospital in China from January 2014 to December 2018. The target-independent variable was LDH measured at baseline, and the dependent was all-cause mortality during hospitalization. Covariates involved in this study included age, gender, body mass index (BMI), hypertension, diabetes, smoking, stroke, atherosclerosis, systolic blood pressure (SBP), diastolic blood pressure (DBP), white blood cell (WBC), hemoglobin (Hb), alanine transaminase (ALT), aspartate aminotransferase (AST), albumin (ALB), creatinine (Cr), symptom, type of AAD (Stanford), and management.
resultsThe average age of 1526 selected participants was 52.72 ± 11.94 years old, and about 80.41% of them were male. The result of the fully adjusted model showed LDH was positively associated with in-hospital mortality in AAD patients after adjusting confounders (OR = 1.09, 95% CI 1.05 to 1.13). A nonlinear relationship was detected between LDH and in-hospital mortality in AAD patients after adjusting for potential confounders (age, gender, BMI, hypertension, diabetes, stroke, atherosclerosis, smoking, symptom, SBP, DBP, WBC, Hb, ALT, AST, ALB, Cr, type of AAD (Stanford), and management), whose point was 557. The effect sizes and the confidence intervals of the left and right sides of the inflection point were 0.90 (0.74-1.10) and 1.12 (1.06-1.19), respectively. Subgroup analysis in participants showed that the relationship between LDH and in-hospital mortality was stable, and all of the
conclusionsThe relationship between LDH and in-hospital mortality in AAD patients is nonlinear. LDH was positively related with in-hospital mortality when LDH is more than 557.
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