Evidence map›Paper›PMID 31969991›Full record

ArticleNPJ vaccines2020

Combined proteomics/miRNomics of dendritic cell immunotherapy-treated glioblastoma patients as a screening for survival-associated factors.

Friedrich Erhart, Matthias Hackl, Hannes Hahne, Johanna Buchroithner, Chen Meng, Simone Klingenbrunner, René Reitermaier, Katrin Fischhuber, Susanna Skalicky, Walter Berger and 11 more

Abstract read
In one paragraph

Article in NPJ vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Oncolytic viruses: advanced strategies in cancer therapy.Signal transduction and targeted therapy · 2026
    Review
  3. Review
  4. Huntingtin-interacting protein 1 in cancer progression: a path less explored.Medical oncology (Northwood, London, England) · 2025
    Review
  5. Review
  6. Biomarkers of immunotherapy in glioblastoma.Neuro-oncology practice · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Laryngeal Squamous Cell Carcinoma: Potential Molecular Mechanism and Prognostic Signature Based on Immune-Related Genes.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Friedrich Erhart1Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-9708-3126
Matthias HacklTAmiRNA GesmbH, Vienna, Austria.
Hannes HahneOmicScouts GmbH, Freising, Germany.
Johanna Buchroithner6University Clinic for Neurosurgery, Kepler University Hospital, Johannes Kepler University, Linz, Austria.
Chen Meng7Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
Simone KlingenbrunnerActivartis Biotech GmbH, Vienna, Austria.
René ReitermaierActivartis Biotech GmbH, Vienna, Austria.
Katrin FischhuberActivartis Biotech GmbH, Vienna, Austria.
Susanna SkalickyTAmiRNA GesmbH, Vienna, Austria.
Walter Berger9Institute for Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Sabine Spiegl-Kreinecker6University Clinic for Neurosurgery, Kepler University Hospital, Johannes Kepler University, Linz, Austria.
Daniela Lötsch9Institute for Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Gerda Ricken2Institute of Neurology, Medical University of Vienna, Vienna, Austria.
Bernhard Kuster7Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
Adelheid Wöhrer2Institute of Neurology, Medical University of Vienna, Vienna, Austria.
Georg Widhalm1Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.
Johannes Hainfellner2Institute of Neurology, Medical University of Vienna, Vienna, Austria.
Thomas FelzmannActivartis Biotech GmbH, Vienna, Austria.
Alexander M Dohnal3Department of Tumor Immunology, St. Anna Kinderkrebsforschung Children's Cancer Research Institute, Vienna, Austria.
Christine Marosi11Clinical Division of Medical Oncology, Medical University of Vienna, Vienna, Austria.
Carmen VisusActivartis Biotech GmbH, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma is the most prevalent and aggressive brain cancer. With a median overall survival of ~15-20 months under standard therapy, novel treatment approaches are desperately needed. A recent phase II clinical trial with a personalized immunotherapy based on tumor lysate-charged dendritic cell (DC) vaccination, however, failed to prolong survival. Here, we investigated tumor tissue from trial patients to explore glioblastoma survival-related factors. We followed an innovative approach of combining mass spectrometry-based quantitative proteomics (

Indexed as

Cancer therapyCell vaccinesCNS cancerTranslational researchTumour immunology

Identifiers

PMID31969991
PMCPMC6965118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.