Evidence map›Paper›PMID 31969797›Full record

ArticleContrast media & molecular imaging2019

Fe-HBED Analogs: A Promising Class of Iron-Chelate Contrast Agents for Magnetic Resonance Imaging.

Brian C Bales, Brian Grimmond, Bruce F Johnson, M Todd Luttrell, Dan E Meyer, Tatyana Polyanskaya, Michael J Rishel, Jeannette Roberts

Abstract read
In one paragraph

Article in Contrast media & molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Synthesis, Characterization, and Magnetic Properties of Fe(BIP)Pharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Fe(III)Inorganic chemistry · 2023
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Enzyme Control Over Ferric Iron Magnetostructural Properties.Angewandte Chemie (International ed. in English) · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brian C BalesGE Research, Niskayuna, NY 12309, USA.
Brian GrimmondGE Research, Niskayuna, NY 12309, USA.
Bruce F JohnsonGE Research, Niskayuna, NY 12309, USA.ORCID 0000-0002-8766-0073
M Todd LuttrellGE Research, Niskayuna, NY 12309, USA.
Dan E MeyerGE Research, Niskayuna, NY 12309, USA.ORCID 0000-0002-1574-1704
Tatyana PolyanskayaGE Research, Niskayuna, NY 12309, USA.
Michael J RishelGE Research, Niskayuna, NY 12309, USA.
Jeannette RobertsGE Research, Niskayuna, NY 12309, USA.ORCID 0000-0002-7460-8495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contrast-enhanced magnetic resonance imaging is an essential tool for disease diagnosis and management; all marketed clinical magnetic resonance imaging (MRI) contrast agents (CAs) are gadolinium (Gd) chelates and most are extracellular fluid (ECF) agents. After intravenous injection, these agents rapidly distribute to the extracellular space and are also characterized by low serum protein binding and predominant renal clearance. Gd is an abiotic element with no biological recycling processes; low levels of Gd have been detected in the central nervous system and bone long after administration. These observations have prompted interest in the development of new MRI contrast agents based on biotic elements such as iron (Fe); Fe-HBED (HBED =

Indexed as

AnimalsContrast MediaEdetic AcidGadoliniumGadolinium DTPAHumansIron Chelating AgentsLiverMagnetic Resonance ImagingMiceMolecular StructureOrganometallic CompoundsTissue DistributionContrast MediaEdetic AcidFe-HBEDGadoliniumGadolinium DTPAIron Chelating AgentsOrganometallic Compounds

Identifiers

PMID31969797
PMCPMC6961518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.