ArticleNature2020
Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 222 papers.
0numbers the graph read from it
0cells of the map it votes in
222citing papers in PubMed
27.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
222 citing papers in PubMed, 313 citations in OpenAlex.
- Trial
- Article
- Empirical PK/PD Model for Differentiating Intrinsic Dosing Rules by Therapeutic Indication With Relevance for HIV-1 Latency Reversal.Clinical pharmacology and therapeutics · 2026Article
- Natural killer cells against viral infection: from basic biology to immunotherapy.Precision clinical medicine · 2026Review
- Effect of ligands and HIV latency-reversing agents on estrogen receptor α in CD4+ T cells.JCI insight · 2026Article
- A screen of chromatin-targeting compounds identifies TAF1 as a novel regulator of HIV latency.mBio · 2026Article
- Limited Sex-Based Differences in Viral Outcomes of ART-Treated SIV/SHIV Infection.The Journal of infectious diseases · 2026Article
- AZD5582 robustly reactivates latently infected cells and clears the majority of those reactivated from the SIV reservoir.bioRxiv : the preprint server for biology · 2026Article
- The Gut Microbiome in HIV Pathogenesis: Interconnections Between Dysbiosis, Immune Dysfunction, and Viral Persistence.International journal of molecular sciences · 2026Review
- Blocking Host Factors IAP and DDX3 Activates HIV-1 Transcription and Increases Apoptosis Sensitivity of HIV-1 Infected Cells.Pathogens (Basel, Switzerland) · 2026Article
- Article
- Smac mimetic combined with eCD4-Ig reverses latency without reducing SHIV reservoirs in rhesus macaques.The Journal of clinical investigation · 2026Article
- Transcription of HIV-1 is heterogenous among authentic latent CD4+ T cell clones.The Journal of experimental medicine · 2026Article
- A novel antiviral strategy by disrupting the equilibrium of virus-host calcium homeostasis.Current opinion in virology · 2026Review
- World free HIV: the novel therapeutic approaches for eliminating latent HIV infection.Virology journal · 2026Review
- Harziachalasins A-G, polycyclic-fused cytochalasins from the endophytic fungus Trichoderma harzianum MLJ-4 with HIV latency reversal activity.Natural products and bioprospecting · 2026Article
- Astragalus polysaccharide promotes latent HIV-1 reactivation via exosome-mediated modulation of the PI3K/AKT/NF-κB axis.Extracellular vesicles and circulating nucleic acids · 2026Article
- Article
- HIV-induced sialoglycans on infected CD4+ T cells promote immune evasion from myeloid cell-mediated killing.Nature communications · 2025Article
- Combining spironolactone to antiretroviral therapy accelerates HIV decay in humanized mice.Emerging microbes & infections · 2025Article
162 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
43 authors at 7 institutions in 3 countries.
Christopher C Nixon *International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Maud Mavigner *Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Gavin C SampeyDivision of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alyssa D BrooksDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Rae Ann SpagnuoloInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
David M IrlbeckQura Therapeutics, Chapel Hill, NC, USA.
Cameron MattinglyDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Phong T HoInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nils SchoofDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Corinne G CammonInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Greg K TharpYerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Matthew KankeDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Zhang WangGlaxoSmithKline Research and Development, Collegeville, PA, USA.
Rachel A ClearyInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Amit A UpadhyayYerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Chandrav DeInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Saintedym R WillsDivision of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Shane D FalcinelliDivision of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Cristin GalardiQura Therapeutics, Chapel Hill, NC, USA.
Hasse WalumYerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Nathaniel J SchrammInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jennifer DeutschGlaxoSmithKline Research and Development, Collegeville, PA, USA.
Jeffrey D LifsonAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Christine M FennesseyAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Brandon F KeeleAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Sherrie JeanYerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Sean MaguireGlaxoSmithKline Research and Development, Collegeville, PA, USA.
Baolin LiaoInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Edward P BrowneDivision of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Robert G FerrisQura Therapeutics, Chapel Hill, NC, USA.
Jessica H BrehmQura Therapeutics, Chapel Hill, NC, USA.
David FavreQura Therapeutics, Chapel Hill, NC, USA.
Thomas H VanderfordYerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Steven E BosingerYerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Corbin D JonesDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jean-Pierre RoutyChronic Viral Infection Service, McGill University Health Centre, Montreal, Quebec, Canada.
Nancie M ArchinDivision of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
David M MargolisDivision of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Angela WahlInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Richard M DunhamDivision of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. richard.m.dunham@viivhealthcare.com.
Guido SilvestriYerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Ann ChahroudiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. ann.m.chahroudi@emory.edu.
J Victor GarciaInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. victor_garcia@med.unc.edu.
University of North Carolina at Chapel Hill · USEmory University · USG1 Therapeutics (United States) · USGlaxoSmithKline (United States) · USFrederick National Laboratory for Cancer Research · USGuangzhou Medical University · CNMcGill University Health Centre · CA
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5MYerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MVirology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9MVirology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0MB and T Cell Biology of Protection from and Eradication of SIV/SHIV Infection - Administrative SupplementUM1AI124436 · NIAID · EMORY UNIVERSITY · PI AMARA, RAMA RAO, HUNTER, ERIC · 2016 to 2021
$42.3MUsing NK Cells to eliminate the latent HIV reservoirU19AI096113 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KARN, JONATHAN · 2011 to 2015
$39.5MCollaboratory of AIDS Researchers for Eradication (CARE)UM1AI126619 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARGOLIS, DAVID M. · 2016 to 2020
$23.2MThe Role of Human Gut Microbiota in HIV-1 Rectal Acquisition, Replication, and PathogenesisR01AI123010 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WAHL, ANGELA RAQUEL · 2016 to 2020
$3.7MRole of Myeloid Cells in HIV latency in the Periphery and the CNSR01MH108179 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GARCIA-MARTINEZ, J. VICTOR · 2015 to 2019
$2.7MPlug & Purge: In Vivo Targeting of Active HIV Reservoirs That Persist Despite ARTR01AI111899 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GARCIA-MARTINEZ, J. VICTOR · 2014 to 2018
$2.5MMentoring Multidisciplinary Global HIV Patient-Oriented ResearchK24AI143471 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph David Tucker · 2019 to 2026
$1.4MUNC-South China STD Research Training CenterD43TW009532 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COHEN, MYRON SCOTT, TUCKER, JOSEPH DAVID · 2013 to 2017
$1.3MCCR NIH HHS HHSN261200800001CFIC NIH HHS D43 TW009532NCI NIH HHS 5P30CA016086-41NCI NIH HHS HHSN261200800001ENCI NIH HHS P30 CA016086NIAID NIH HHS AI096113NIAID NIH HHS AI1117851NIAID NIH HHS AI111899NIAID NIH HHS AI123010NIAID NIH HHS K24 AI143471NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI111899NIAID NIH HHS R01 AI123010NIAID NIH HHS R56 AI117851NIAID NIH HHS U19 AI096113NIAID NIH HHS UM1 AI124436NIAID NIH HHS UM1 AI126619NIH HHS P51 OD011132NIH HHS S10 OD026799NIMH NIH HHS MH108179NIMH NIH HHS R01 MH108179NIMH NIH HHS R34 MH119963
Abstract
Long-lasting, latently infected resting CD4
Indexed as
Virus LatencyAlkynesAnimalsAnti-Retroviral AgentsHIV-1HIV InfectionsMacaca mulattaMiceNF-kappa BOligopeptidesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAlkynesAnti-Retroviral AgentsNF-kappa BN,N'-(2,2'-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-(2-cyclohexyl-2-(2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide)Oligopeptides
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.