Evidence map›Paper›PMID 31969701›Full record

ArticleNature2020

Constructing protein polyhedra via orthogonal chemical interactions.

Eyal Golub, Rohit H Subramanian, Julian Esselborn, Robert G Alberstein, Jake B Bailey, Jerika A Chiong, Xiaodong Yan, Timothy Booth, Timothy S Baker, F Akif Tezcan

Abstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Protein Recognition and Assembly by a Phosphocavitand.Journal of the American Chemical Society · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Beyond Dimerization: Harnessing Tetrameric Coiled-Coils for Nanostructure Assembly.Angewandte Chemie (International ed. in English) · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Point mutation in a virus-like capsid drives symmetry reduction to form tetrahedral cages.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eyal GolubDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Rohit H SubramanianDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Julian EsselbornDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Robert G AlbersteinDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Jake B BaileyDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Jerika A ChiongDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Xiaodong YanDivision of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Timothy BoothDivision of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Timothy S BakerDivision of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
F Akif TezcanDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA. tezcan@ucsd.edu.

Funding

MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008326 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 1989 to 2020
$7.5M
Microscopy &Image Analysis of Unstained MacromoleculesR37GM033050 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAKER, TIMOTHY S · 2004 to 2013
$5.6M
Chemistry-Biology Interfaces at UCSDT32GM146648 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael D. Burkart, Alexis C. Komor · 2022 to 2026
$876k
Chemical Biology Interfaces at UC San DiegoT32GM112584 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D. · 2015 to 2019
$729k
NIGMS NIH HHS R37 GM033050NIGMS NIH HHS T32 GM008326NIGMS NIH HHS T32 GM112584NIGMS NIH HHS T32 GM146648
6 · The paper itself

Abstract

Many proteins exist naturally as symmetrical homooligomers or homopolymers

Indexed as

Models, MolecularCoordination ComplexesProteinsCoordination ComplexesProteins

Identifiers

PMID31969701
PMCPMC7007351

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.