ArticleNature2020
Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 1 pooled it
18.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
161 citing papers in PubMed, 1 synthesis or guideline pooled it, 278 citations in OpenAlex.
- The interplay between epidermal cells and the cutaneous sensory nervous: a systematic review.Frontiers in immunology · 2026Pooled it
- Gonadotropin-Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress-Induced Activation of the Locus Coeruleus-SAM Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A two-hit mechanism triggers autoimmune hair loss.Nature · 2026Article
- Leukotrichia: A comprehensive review of follicular depigmentation.The Journal of international medical research · 2026Review
- Aging of hair follicle stem cells and their niche: mechanisms and regenerative therapeutic strategies.Cell communication and signaling : CCS · 2026Review
- Construction of a Modified Pain-Induced Stress White Hair Model.Experimental dermatology · 2026Article
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- A negative survival pressure selection system enables GPCR antagonist screening.Cell discovery · 2026Article
- Targeting Tumour Microtubes to Disrupt Glioma Networks.Research square · 2026Article
- Convergence of external and internal stressors on a stress-responsive enhancer of theProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dissecting the boundary of quiescence and activation of murine melanocyte stem cells in the hair follicle niche.NPJ Regenerative medicine · 2026Review
- Hair Graying as an Evolutionary Checkpoint against Malignancy: a Stem Cell Perspective.Stem cell reviews and reports · 2026Review
- Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Preserve Melanocyte Stem Cell Integrity Under Acute Neurogenic Oxidative Stress via Activation of the Nrf2-ARE Pathway in C57BL/6J Mice.Journal of cosmetic dermatology · 2026Article
- Article
- Natural products and their derivatives as candidate treatments for hair greying: from drug discovery to molecular mechanisms.Chinese medicine · 2026Review
- β-Adrenergic Signaling Contributes to Circadian and Lipid Dysregulation in Meibomian Glands During Chronic Psychological Stress.Investigative ophthalmology & visual science · 2026Article
- NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development.Cell death and differentiation · 2026Article
- Pathogenesis of Chemical Leukoderma and Chemical-Induced Vitiligo.The Journal of dermatology · 2026Review
- Spatiotemporal dynamics of mammalian wound healing.Cell discovery · 2026Review
- Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity.Cell · 2026Article
101 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 2 countries.
Bing ZhangDepartment of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA, USA.
Sai MaDepartment of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA, USA.
Inbal RachminCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Megan HeDepartment of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA, USA.
Pankaj BaralDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Sekyu ChoiDepartment of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA, USA.
William A GonçalvesInstitute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Yulia ShwartzDepartment of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA, USA.
Eva M FastDepartment of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA, USA.
Yiqun SuCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Leonard I ZonDepartment of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA, USA.
Aviv RegevKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jason D BuenrostroDepartment of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA, USA.
Thiago M CunhaDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Isaac M ChiuDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
David E FisherCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Ya-Chieh HsuDepartment of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA, USA. yachieh_hsu@harvard.edu.
Harvard University · USHarvard Stem Cell Institute · USDana-Farber Cancer Institute · USHoward Hughes Medical Institute · USUniversidade de São Paulo · BRUniversidade Federal de Minas Gerais · BR
Funding
Transcriptional mechanisms and melanomaP01CA163222 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LEONARD Ira ZON · 2013 to 2026
$25.3MTraining in Molecular, Cellular, and Chemical BiologyT32GM007598 · NIGMS · HARVARD UNIVERSITY · PI DULAC, CATHERINE · 1985 to 2019
$16.2MThe MITF transcriptional network: melanoma risk and carcinogenesisR01AR043369 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI DAVID E FISHER · 1996 to 2026
$9.4MCancer Biology in the ZebrafishR01CA103846 · NCI · CHILDREN'S HOSPITAL BOSTON · PI ZON, LEONARD IRA · 2003 to 2022
$7.5MTherapeutic strategies for treatment of giant congenital melanocytic neviR01AR072304 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI DAVID E FISHER · 2017 to 2026
$3.9MPain and Neuro-immune Signaling in S. pyogenes pathogenesisR01AI130019 · NIAID · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG, WESSELS, MICHAEL R · 2017 to 2021
$3.2MSensory Neuron-Bacteria Interactions in Modulating Pain and the Host MicrobiotaDP2AT009499 · NCCIH · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG · 2016 to 2019
$2.7MDevelopment of lung T cell responses in infant respiratory immunityR01AI100119 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L. · 2012 to 2016
$2.6MInterdependence of lineages within the mammalian skinR01AR070825 · NIAMS · HARVARD UNIVERSITY · PI HSU, YA-CHIEH · 2016 to 2020
$1.9MA druggable dependency in low-MITF/high-AXL melanoma: preclinical efficacy and mechanism of action in a key treatment-resistant subclass.R01CA222871 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FISHER, DAVID E · 2018 to 2022
$1.8MHoward Hughes Medical InstituteNCCIH NIH HHS DP2 AT009499NCI NIH HHS P01 CA163222NCI NIH HHS R01 CA103846NCI NIH HHS R01 CA222871NIAID NIH HHS R01 AI100119NIAID NIH HHS R01 AI130019NIAMS NIH HHS R01 AR043369NIAMS NIH HHS R01 AR070825NIAMS NIH HHS R01 AR072304NIGMS NIH HHS T32 GM007598NIH HHS R01 AR043369-23
Abstract
Empirical and anecdotal evidence has associated stress with accelerated hair greying (formation of unpigmented hairs)
Indexed as
AdrenalectomyAdrenal GlandsAnimalsAutonomic PathwaysCell ProliferationCells, CulturedDenervationFemaleHair ColorHumansMaleMelanocytesMiceNorepinephrinePsychological TraumaReceptors, Adrenergic, beta-2ADRB2 protein, humanNorepinephrineReceptors, Adrenergic, beta-2
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.