ArticleScientific reports2020
Intrinsic sensory disinhibition contributes to intrusive re-experiencing in combat veterans.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Machine learning and individual variability in electric field characteristics predict tDCS treatment response.Brain stimulationTrial
- Identification of an intrusive-hypervigilant phenotype of posttraumatic stress symptoms with unique stress peptide and amygdala functional connectivity profiles.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Characteristic spatiotemporal features of large-scale functional network architecture in posttraumatic stress disorder.Translational psychiatry · 2026Article
- A disaster in the disaster: a study on post-traumatic stress symptoms among flood relief workers in Pakistan.BMC psychology · 2026Article
- Microstructural Integrity of Hippocampal-Posterior Cortical White Matter Is Associated With Phenomenological Properties of Trauma-Related Intrusive Memories.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Trait-like visual cortical hyperactivity in trait anxiety.Nature communications · 2025Article
- Anxious vision: Trait-like visual cortical hyperactivity in trait anxiety.bioRxiv : the preprint server for biology · 2025Article
- The value of multimodal neuroimaging in the diagnosis and treatment of post-traumatic stress disorder: a narrative review.Translational psychiatry · 2025Review
- Systematic review and meta-analysis of neurofeedback training efficacy and neural mechanisms in the treatment of posttraumatic stress disorder.Frontiers in neuroscience · 2025Article
- Neuromodulation of Fear and Anxiety Circuits.Current topics in behavioral neurosciences · 2025Review
- Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories.Molecular psychiatry · 2024Article
- Evaluating a novel 8-factor dimensional model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study.Journal of affective disorders · 2024Article
- Sensory alterations in post-traumatic stress disorder.Current opinion in neurobiology · 2024Review
- Daily life participation in PTSD: pilot study on patterns and correlators.Frontiers in psychiatry · 2024Article
- Pattern differentiation and tuning shift in human sensory cortex underlie long-term threat memory.Current biology : CB · 2022Article
- Transcranial stimulation of alpha oscillations up-regulates the default mode network.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Human Sensory Cortex Contributes to the Long-Term Storage of Aversive Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Intrusive re-experiencing of traumatic events is a hallmark symptom of posttraumatic stress disorder, characterized by rich and vivid sensory details as reported in "flashbacks". While prevailing models of trauma intrusions focus on dysregulated emotional processes, we hypothesize that a deficiency in intrinsic sensory inhibition could drive overactivation of sensory representations of trauma memories, precipitating sensory-rich intrusions. In a sample of combat veterans, we examined resting-state alpha (8-12 Hz) oscillatory activity (in both power and posterior→frontal connectivity), given its role in sensory cortical inhibition, in association with intrusive re-experiencing symptoms. Veterans further participated in an odor task (including both combat and non-combat odors) to assess olfactory trauma memory and emotional response. We observed an association between intrusive re-experiencing symptoms and attenuated resting-state posterior→frontal alpha connectivity, which were both correlated with olfactory trauma memory. Importantly, olfactory trauma memory was identified as a mediator of the relationship between alpha connectivity and intrusive re-experiencing, suggesting that deficits in intrinsic sensory inhibition contributed to intrusive re-experiencing of trauma via heightened trauma memory. Therefore, by permitting unfiltered sensory cues to enter information processing and activate sensory representations of trauma, sensory disinhibition can constitute a sensory mechanism of intrusive re-experiencing in trauma-exposed individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.