ArticleScientific reports2020
Evolutionary history of DNA methylation related genes in chordates: new insights from multiple whole genome duplications.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 49 citations in OpenAlex.
- A mammalian-like piRNA pathway in Axolotl reveals the origins of piRNA-directed DNA methylation.The EMBO journal · 2026Article
- The Influence of CG sites on dynamic DNA sequence mutagenesis in the genomic evolution of mammalian lifespan.Nucleic acids research · 2025Article
- Annelid methylomes reveal ancestral developmental and aging-associated epigenetic erosion across Bilateria.Genome biology · 2024Article
- Parental thermal environment controls the offspring phenotype in Brook charr (Salvelinus fontinalis): insights from a transcriptomic study.G3 (Bethesda, Md.) · 2024Article
- Active DNA demethylation of developmentalScience advances · 2022Article
- A plant-based diet differentially affects the global hepatic methylome in rainbow trout depending on genetic background.Epigenetics · 2022Article
- Environment-driven reprogramming of gamete DNA methylation occurs during maturation and is transmitted intergenerationally in Atlantic Salmon.G3 (Bethesda, Md.) · 2021Article
- Effects of Cadmium Sulfate on the Brown Garden SnailToxics · 2021Article
- Dnmt3aa but Not Dnmt3ab Is Required for Maintenance of Gametogenesis in Nile Tilapia (International journal of molecular sciences · 2021Article
- Sources of variation of DNA methylation in rainbow trout: combined effects of temperature and genetic background.Epigenetics · 2021Article
- DNA methylation atlas and machinery in the developing and regenerating annelid Platynereis dumerilii.BMC biology · 2021Article
- Article
- The emergence of the brain non-CpG methylation system in vertebrates.Nature ecology & evolution · 2021Article
- Myxosporea (Myxozoa, Cnidaria) Lack DNA Cytosine Methylation.Molecular biology and evolution · 2021Article
- Flanking sequence preference modulates de novo DNA methylation in the mouse genome.Nucleic acids research · 2021Article
- Article
- Developmental remodelling of non-CG methylation at satellite DNA repeats.Nucleic acids research · 2020Article
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Authors and funding
4 authors at 2 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
DNA methylation is an important epigenetic mechanism involved in many biological processes, i.e. gametogenesis and embryonic development. However, increased copy numbers of DNA methylation related genes (dnmt, tet and tdg) have been found during chordate evolution due to successive whole genome duplication (WGD) events. Their evolutionary history and phylogenetic relationships remain unclear. The present study is the first to clarify the evolutionary history of DNA methylation genes in chordates. In particular, our results highlight the fixation of several dnmt3-related genes following successive WGD throughout evolution. The rainbow trout genome offered a unique opportunity to study the early evolutionary fates of duplicated genes due to a recent round of WGD at the radiation of salmonids. Differences highlighted in transcriptional patterns of these genes during gametogenesis and ontogenesis in trout indicated that they might be subjected to sub- or neo-functionalisation after WDG. The fixation of multiple dnmt3 genes in genomes after WGD could contribute to the diversification and plastic adaptation of the teleost.
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