Evidence map›Paper›PMID 31969605›Full record

ArticleScientific reports2020

A Cellular Mechanism of Learning-Induced Enhancement of Synaptic Inhibition: PKC-Dependent Upregulation of KCC2 Activation.

Adi Kfir, Richa Awasthi, Sourav Ghosh, Sankhanava Kundu, Blesson Paul, Raphael Lamprecht, Edi Barkai

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. The Role of Astrocytes in the Modulation ofKInternational journal of molecular sciences · 2020
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Adi KfirSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
Richa AwasthiSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
Sourav GhoshSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
Sankhanava KunduSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.ORCID http://orcid.org/0000-0002-7232-9513
Blesson PaulSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
Raphael LamprechtSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
Edi BarkaiSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel. ebarkai@research.haifa.ac.il.
University of Haifa · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term memory of complex olfactory learning is expressed by wide spread enhancement in excitatory and inhibitory synaptic transmission onto piriform cortex pyramidal neurons. A particularly interesting modification in synaptic inhibition is the hyperpolarization of the reversal potential of the fast post synaptic inhibitory potential (fIPSP). Here we study the mechanism underlying the maintenance of such a shift in the fIPSP. Blocking of the neuronal specific K

Indexed as

AnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Discrimination LearningEnzyme InhibitorsK Cl- CotransportersMaleMiniature Postsynaptic PotentialsNeural InhibitionNeuronsPhosphorylationProtein Kinase CRatsRats, Sprague-DawleySignal TransductionSmellSymportersCalcium-Calmodulin-Dependent Protein Kinase Type 2Enzyme InhibitorsK Cl- CotransportersProtein Kinase CSymporters

Identifiers

PMID31969605
PMCPMC6976593
OpenAlexW3002329732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.