ArticleScientific reports2020
Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases.Clinical epigenetics · 2020Trial
- Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis.Clinical epigenetics · 2020Trial
- Prenatal over-the-counter acetaminophen use and birth outcomes in the ECHO Cohort.American journal of epidemiology · 2026Article
- Cord Blood DNA Methylation and Large-for-Gestational-Age Birth: A Pilot Epigenome-Wide Study in the GROW Cohort.Epigenomes · 2026Article
- First-Trimester Serum n-3/n-6 Fatty Acids Predict Large-for-Gestational-Age Risk: A Nested Case-Control Study.Maternal & child nutrition · 2026Article
- Impact of Wildland Fire Smoke PMEnvironmental science & technology · 2026Article
- Cord Blood DNA Methylation at CHD13 Is Associated with Adiponectin Levels at 10 to 14 Years of Age.The Journal of clinical endocrinology and metabolism · 2026Article
- The role of placental DNA methylation in the pathogenesis of chronic intervillositis of unknown etiology.Clinical epigenetics · 2025Article
- Changed expression of placental transporters and disrupted epigenetic patterns in a rat model of schizophrenia.Frontiers in pharmacology · 2025Article
- Gestational DNA methylation age as a marker for fetal development and birth outcomes: findings from the Boston Birth Cohort.Clinical epigenetics · 2024Article
- Associations between placental hydroxymethylation and birthweight.Epigenetics reports · 2024Article
- Maternal mitochondrial DNA copy number and methylation as possible predictors of pregnancy outcomes in a Michigan pregnancy cohort.Environmental epigenetics · 2024Article
- Influence of maternal psychological distress during COVID-19 pandemic on placental morphometry and texture.Scientific reports · 2023Article
- The likelihood of a healthy live birth after frozen embryo transfer with endometrium prepared by natural ovulation regimen vs programmed regimen: a propensity-score matching study.AJOG global reports · 2023Article
- Maternal PUFAs, Placental Epigenetics, and Their Relevance to Fetal Growth and Brain Development.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Genome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors.Clinical epigenetics · 2022Article
- Residential green space in association with the methylation status in a CpG site within the promoter region of the placental serotonin receptorEpigenetics · 2022Article
- Time-Specific Factors Influencing the Development of Asthma in Children.Biomedicines · 2022Review
- Impact of mode of conception on early pregnancy human chorionic gonadotropin rise and birth weight.F&S reports · 2022Article
- Extensive Placental Methylation Profiling in Normal Pregnancies.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Being born small (SGA) or large for gestational age (LGA) is associated with adverse birth outcomes and metabolic diseases in later life of the offspring. It is known that aberrations in growth during gestation are related to altered placental function. Placental function is regulated by epigenetic mechanisms such as DNA methylation. Several studies in recent years have demonstrated associations between altered patterns of DNA methylation and adverse birth outcomes. However, larger studies that reliably investigated global DNA methylation are lacking. The aim of this study was to characterize global placental DNA methylation in relationship to size for gestational age. Global DNA methylation was assessed in 1023 placental samples by LC-MS/MS. LGA offspring displayed significantly higher global placental DNA methylation compared to appropriate for gestational age (AGA; p < 0.001). ANCOVA analyses adjusted for known factors impacting on DNA methylation demonstrated an independent association between placental global DNA methylation and LGA births (p < 0.001). Tertile stratification according to global placental DNA methylation levels revealed a significantly higher frequency of LGA births in the third tertile. Furthermore, a multiple logistic regression analysis corrected for known factors influencing birth weight highlighted an independent positive association between global placental DNA methylation and the frequency of LGA births (p = 0.001).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.