ArticleScientific reports2020
A possible role for autoimmunity through molecular mimicry in alphavirus mediated arthritis.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Autoantibodies and Molecular Mimicry in Alphavirus Chronic Arthritis: A Systematic Review.Pathogens (Basel, Switzerland) · 2026Pooled it
- Serum autoantibodyome reveals that healthy individuals share common autoantibodies.Cell reports · 2022Pooled it
- Emerging and underrecognized viral triggers of autoimmune inflammatory rheumatic disease flares.Nature reviews. Rheumatology · 2026Review
- Immunopathological mechanisms and targeted intervention strategies for chronic chikungunya arthritis: from viral persistence to autoimmunity.Frontiers in immunology · 2026Review
- Viruses and Mitochondrial Dysfunction in Neurodegeneration and Cognition: An Evolutionary Perspective.Cellular and molecular neurobiology · 2024Review
- Latent microbial infections leading to myelin and axonal damage in multiple sclerosis: A narrative review.Current journal of neurology · 2024Article
- Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates inMicroorganisms · 2023Article
- Autoantibodies to Interferons in Infectious Diseases.Viruses · 2023Review
- Mosquito-borne viruses causing human disease in Fennoscandia-Past, current, and future perspectives.Frontiers in medicine · 2023Review
- Role of Arbovirus Infection in Arthritogenic Pain Manifestation-A Systematic Review.Tropical medicine and infectious disease · 2022Review
- Molecular Mimicry Analyses Unveiled the Human Herpes Simplex and Poxvirus Epitopes as Possible Candidates to Incite Autoimmunity.Pathogens (Basel, Switzerland) · 2022Article
- ImitateDB: A database for domain and motif mimicry incorporating host and pathogen protein interactions.Amino acids · 2022Article
- Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self.Circulation research · 2022Article
- Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression.Emerging microbes & infections · 2021Article
- Epitope mimicry analysis of SARS-COV-2 surface proteins and human lung proteins.Journal of molecular graphics & modelling · 2021Article
- Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity.Cellular & molecular immunology · 2021Review
- Persistent Joint Pain Following Arthropod Virus Infections.Current rheumatology reports · 2021Review
- Significant non-existence of sequences in genomes and proteomes.Nucleic acids research · 2021Article
- Article
- Emerging Concepts in Immune Thrombotic Thrombocytopenic Purpura.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alphaviral infections are foremost in causing debilitating clinical outcomes in humans characterized by rheumatic arthritis like conditions. Though the presence of virus in joints and associated inflammation has been implicated as one of the reasons for the acute and chronic polyarthritis post alphaviral infections, the basis for rheumatic like outcomes is not clear. Through an in silico analysis, we have investigated the possibility of an autoimmune process mediated through molecular mimicry in alphaviral infection induced pathogenicity. Interestingly, sequence alignment of the structural polyproteins belonging to arthritogenic alphaviruses revealed conserved regions which share homology with human proteins implicated in rheumatoid arthritis (RA). These conserved regions were predicted to exhibit binding to HLA class II alleles, showcasing their potential to incite T cell help. Molecular docking of the viral peptide and the corresponding homologous region in the human protein onto HLA-DRB1 revealed strong similarities in their binding patterns. Linear and conformational B cell epitope prediction analyses showed that these potential mimics have high propensity to elicit an efficient B cell response. We thus propose that the origin of polyarthritis post-arthritogenic alphaviral infections may also be mediated through a hitherto unknown autoimmune response due to the presence of cross-reactive epitopes between viral and human proteins.
Indexed as
Identifiers
31969581PMC6976597W3002528879What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.