Evidence map›Paper›PMID 31969575›Full record

ArticleScientific reports2020

A Common Practice of Widespread Antimicrobial Use in Horse Production Promotes Multi-Drug Resistance.

S Álvarez-Narváez, L J Berghaus, E R A Morris, J M Willingham-Lane, N M Slovis, S Giguere, N D Cohen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Exploring the Accessory Genome of Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Article
  8. Antibiotics (Basel, Switzerland) · 2023
    Article
  9. Article
  10. Review
  11. Fatal Infection in an Alpaca (Animals : an open access journal from MDPI · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. A review of the resistome within the digestive tract of livestock.Journal of animal science and biotechnology · 2021
    Review
  17. Serum Antibody Activity against Poly-Microbiology spectrum · 2021
    Article
  18. Article
  19. Epidemiology and Molecular Basis of Multidrug Resistance in Rhodococcus equi.Microbiology and molecular biology reviews : MMBR · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

S Álvarez-NarváezDepartment of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, Ga, USA.
L J BerghausDepartment of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, Ga, USA.
E R A MorrisDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0002-7957-4642
J M Willingham-LaneDepartment of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, Ga, USA.
N M SlovisHagyard Equine Medical Institute, Lexington, KY, USA.
S GiguereDepartment of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, Ga, USA.
N D CohenDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA. ncohen@cvm.tamu.edu.ORCID http://orcid.org/0000-0002-0384-2903

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The practice of prophylactic administration of a macrolide antimicrobial with rifampin (MaR) to apparently healthy foals with pulmonary lesions identified by thoracic ultrasonography (i.e., subclinically pneumonic foals) is common in the United States. The practice has been associated epidemiologically with emergence of R. equi resistant to MaR. Here, we report direct evidence of multi-drug resistance among foals treated with MaR. In silico and in vitro analysis of the fecal microbiome and resistome of 38 subclinically pneumonic foals treated with either MaR (n = 19) or gallium maltolate (GaM; n = 19) and 19 untreated controls was performed. Treatment with MaR, but not GaM, significantly decreased fecal microbiota abundance and diversity, and expanded the abundance and diversity of antimicrobial resistance genes in feces. Soil plots experimentally infected with Rhodococcus equi (R. equi) and treated with MaR selected for MaR-resistant R. equi, whereas MaR-susceptible R. equi out-competed resistant isolates in GaM-treated or untreated plots. Our results indicate that MaR use promotes multi-drug resistance in R. equi and commensals that are shed into their environment where they can persist and potentially infect or colonize horses and other animals.

Indexed as

Antibiotic ProphylaxisAnimalsAnti-Bacterial AgentsDrug Resistance, MultipleFecesHorse DiseasesHorsesMacrolidesMicrobial Sensitivity TestsOrganometallic CompoundsPneumonia, BacterialPyronesRhodococcus equiRifampinAnti-Bacterial Agentsgallium maltolateMacrolidesOrganometallic CompoundsPyronesRifampin

Identifiers

PMID31969575
PMCPMC6976650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.