ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Complementary Control over Habits and Behavioral Vigor by Phasic Activity in the Dorsolateral Striatum.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Continuous contributions of the dorsolateral striatum to movement initiation and execution.Science advances · 2026Article
- Distributed activity in the human posterior putamen distinguishes goal-directed from habitual control.bioRxiv : the preprint server for biology · 2026Article
- Neurodegenerative Disease Movement Disorders and Dorsal Striatum-Mediated Imbalance of Habitual Motor Sequences.Molecular neurobiology · 2025Review
- Nicotine enhances the ability of cues to control behavior and evoke dopamine release in the dorsolateral striatum.The Journal of pharmacology and experimental therapeutics · 2025Article
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- Making and breaking habits: Revisiting the definitions and behavioral factors that influence habits in animals.Journal of the experimental analysis of behavior · 2024Review
- Inhibitory Pedunculopontine Neurons Gate Dopamine-Mediated Motor Actions of Unsigned Valence.Current neuropharmacology · 2024Article
- Characterization of striatal dopamine projections across striatal subregions in behavioral flexibility.The European journal of neuroscience · 2023Article
- Enhancing reinforcement learning models by including direct and indirect pathways improves performance on striatal dependent tasks.PLoS computational biology · 2023Article
- Medial Prefrontal Cortex to Medial Septum Pathway Activation Improves Cognitive Flexibility in Rats.The international journal of neuropsychopharmacology · 2023Article
- Lack of action monitoring as a prerequisite for habitual and chunked behavior: Behavioral and neural correlates.iScience · 2023Article
- Medial septum activation improves strategy switching once strategies are well-learned via bidirectional regulation of dopamine neuron population activity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Micro-habits for life-long learning.Abdominal radiology (New York) · 2021Article
- Dorsolateral Striatal Task-initiation Bursts Represent Past Experiences More than Future Action Plans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Spatially restricted inhibition of cholinergic interneurons in the dorsolateral striatum encourages behavioral exploration.The European journal of neuroscience · 2021Article
- Dorsolateral Striatal proBDNF Improves Reversal Learning by Enhancing Coordination of Neural Activity in Rats.Molecular neurobiology · 2020Article
- Mechanisms of Network Interactions for Flexible Cortico-Basal Ganglia-Mediated Action Control.eNeuroArticle
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Authors and funding
6 authors.
Funding
Abstract
Despite clear evidence linking the basal ganglia to the control of outcome insensitivity (i.e., habit) and behavioral vigor (i.e., its behavioral speed/fluidity), it remains unclear whether or how these functions relate to one another. Here, using male Long-Evans rats in response-based and cue-based maze-running tasks, we demonstrate that phasic dorsolateral striatum (DLS) activity occurring at the onset of a learned behavior regulates how vigorous and habitual it is. In a response-based task, brief optogenetic excitation at the onset of runs decreased run duration and the occurrence of deliberative behaviors, whereas midrun stimulation carried little effect. Outcome devaluation showed these runs to be habitual. DLS inhibition at run start did not produce robust effects on behavior until after outcome devaluation. At that time, when the DLS was plausibly most critically required for performance (i.e., habitual), inhibition reduced performance vigor measures and caused a dramatic loss of habitual responding (i.e., animals quit the task). In a second cue-based "beacon" task requiring behavior initiation at the start of the run and again in the middle of the run, DLS excitation at both time points could improve the vigor of runs. Postdevaluation testing showed behavior on the beacon task to be habitual as well. This pattern of results suggests that one role for phasic DLS activity at behavior initiation is to promote the execution of the behavior in a vigorous and habitual fashion by a diverse set of measures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.