Evidence map›Paper›PMID 31969467›Full record

ArticleNeurology2020

Race/ethnicity influences outcomes in young adults with supratentorial intracerebral hemorrhage.

Laura C Miyares, Guido J Falcone, Audrey Leasure, Opeolu Adeoye, Fu-Dong Shi, Steven J Kittner, Carl Langefeld, Achala Vagal, Kevin N Sheth, Daniel Woo

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Article
  4. Article
  5. Article
  6. More severe initial manifestations and worse short-term functional outcome of intracerebral hemorrhage in the plateau than in the plain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  7. Article
  8. Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage.International journal of molecular sciences · 2022
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Laura C MiyaresFrom the Division of Neurocritical Care and Emergency Neurology, Department of Neurology (L.C.M., G.J.F., A.L., K.N.S.), Yale School of Medicine, New Haven, CT; Department of Emergency Medicine (O.A.), Department of Radiology (A.V.), Gardner Neuroscience Institute (O.A., A.V.), Department of Neurology & Rehabilitation Medicine (D.W.), and Comprehensive Stroke Center (D.W.), University of Cincinnati, OH; Barrow Neurological Institute (F.-D.S.), Phoenix, AZ; Department of Neurology (S.J.K.), Baltimore Veterans Administration Medical Center, University of Maryland; Division of Public Health Sciences, Department of Biostatistical Sciences (C.L.), Wake Forest University School of Medicine, Winston-Salem, NC; and Center for Public Health Genomics (C.L.), University of Virginia, Charlottesville.
Guido J FalconeFrom the Division of Neurocritical Care and Emergency Neurology, Department of Neurology (L.C.M., G.J.F., A.L., K.N.S.), Yale School of Medicine, New Haven, CT; Department of Emergency Medicine (O.A.), Department of Radiology (A.V.), Gardner Neuroscience Institute (O.A., A.V.), Department of Neurology & Rehabilitation Medicine (D.W.), and Comprehensive Stroke Center (D.W.), University of Cincinnati, OH; Barrow Neurological Institute (F.-D.S.), Phoenix, AZ; Department of Neurology (S.J.K.), Baltimore Veterans Administration Medical Center, University of Maryland; Division of Public Health Sciences, Department of Biostatistical Sciences (C.L.), Wake Forest University School of Medicine, Winston-Salem, NC; and Center for Public Health Genomics (C.L.), University of Virginia, Charlottesville.
Audrey LeasureFrom the Division of Neurocritical Care and Emergency Neurology, Department of Neurology (L.C.M., G.J.F., A.L., K.N.S.), Yale School of Medicine, New Haven, CT; Department of Emergency Medicine (O.A.), Department of Radiology (A.V.), Gardner Neuroscience Institute (O.A., A.V.), Department of Neurology & Rehabilitation Medicine (D.W.), and Comprehensive Stroke Center (D.W.), University of Cincinnati, OH; Barrow Neurological Institute (F.-D.S.), Phoenix, AZ; Department of Neurology (S.J.K.), Baltimore Veterans Administration Medical Center, University of Maryland; Division of Public Health Sciences, Department of Biostatistical Sciences (C.L.), Wake Forest University School of Medicine, Winston-Salem, NC; and Center for Public Health Genomics (C.L.), University of Virginia, Charlottesville.ORCID 0000-0002-9462-5022
Opeolu AdeoyeFrom the Division of Neurocritical Care and Emergency Neurology, Department of Neurology (L.C.M., G.J.F., A.L., K.N.S.), Yale School of Medicine, New Haven, CT; Department of Emergency Medicine (O.A.), Department of Radiology (A.V.), Gardner Neuroscience Institute (O.A., A.V.), Department of Neurology & Rehabilitation Medicine (D.W.), and Comprehensive Stroke Center (D.W.), University of Cincinnati, OH; Barrow Neurological Institute (F.-D.S.), Phoenix, AZ; Department of Neurology (S.J.K.), Baltimore Veterans Administration Medical Center, University of Maryland; Division of Public Health Sciences, Department of Biostatistical Sciences (C.L.), Wake Forest University School of Medicine, Winston-Salem, NC; and Center for Public Health Genomics (C.L.), University of Virginia, Charlottesville.
Fu-Dong ShiFrom the Division of Neurocritical Care and Emergency Neurology, Department of Neurology (L.C.M., G.J.F., A.L., K.N.S.), Yale School of Medicine, New Haven, CT; Department of Emergency Medicine (O.A.), Department of Radiology (A.V.), Gardner Neuroscience Institute (O.A., A.V.), Department of Neurology & Rehabilitation Medicine (D.W.), and Comprehensive Stroke Center (D.W.), University of Cincinnati, OH; Barrow Neurological Institute (F.-D.S.), Phoenix, AZ; Department of Neurology (S.J.K.), Baltimore Veterans Administration Medical Center, University of Maryland; Division of Public Health Sciences, Department of Biostatistical Sciences (C.L.), Wake Forest University School of Medicine, Winston-Salem, NC; and Center for Public Health Genomics (C.L.), University of Virginia, Charlottesville.
Steven J KittnerFrom the Division of Neurocritical Care and Emergency Neurology, Department of Neurology (L.C.M., G.J.F., A.L., K.N.S.), Yale School of Medicine, New Haven, CT; Department of Emergency Medicine (O.A.), Department of Radiology (A.V.), Gardner Neuroscience Institute (O.A., A.V.), Department of Neurology & Rehabilitation Medicine (D.W.), and Comprehensive Stroke Center (D.W.), University of Cincinnati, OH; Barrow Neurological Institute (F.-D.S.), Phoenix, AZ; Department of Neurology (S.J.K.), Baltimore Veterans Administration Medical Center, University of Maryland; Division of Public Health Sciences, Department of Biostatistical Sciences (C.L.), Wake Forest University School of Medicine, Winston-Salem, NC; and Center for Public Health Genomics (C.L.), University of Virginia, Charlottesville.
Carl LangefeldFrom the Division of Neurocritical Care and Emergency Neurology, Department of Neurology (L.C.M., G.J.F., A.L., K.N.S.), Yale School of Medicine, New Haven, CT; Department of Emergency Medicine (O.A.), Department of Radiology (A.V.), Gardner Neuroscience Institute (O.A., A.V.), Department of Neurology & Rehabilitation Medicine (D.W.), and Comprehensive Stroke Center (D.W.), University of Cincinnati, OH; Barrow Neurological Institute (F.-D.S.), Phoenix, AZ; Department of Neurology (S.J.K.), Baltimore Veterans Administration Medical Center, University of Maryland; Division of Public Health Sciences, Department of Biostatistical Sciences (C.L.), Wake Forest University School of Medicine, Winston-Salem, NC; and Center for Public Health Genomics (C.L.), University of Virginia, Charlottesville.
Achala VagalFrom the Division of Neurocritical Care and Emergency Neurology, Department of Neurology (L.C.M., G.J.F., A.L., K.N.S.), Yale School of Medicine, New Haven, CT; Department of Emergency Medicine (O.A.), Department of Radiology (A.V.), Gardner Neuroscience Institute (O.A., A.V.), Department of Neurology & Rehabilitation Medicine (D.W.), and Comprehensive Stroke Center (D.W.), University of Cincinnati, OH; Barrow Neurological Institute (F.-D.S.), Phoenix, AZ; Department of Neurology (S.J.K.), Baltimore Veterans Administration Medical Center, University of Maryland; Division of Public Health Sciences, Department of Biostatistical Sciences (C.L.), Wake Forest University School of Medicine, Winston-Salem, NC; and Center for Public Health Genomics (C.L.), University of Virginia, Charlottesville.
Kevin N ShethFrom the Division of Neurocritical Care and Emergency Neurology, Department of Neurology (L.C.M., G.J.F., A.L., K.N.S.), Yale School of Medicine, New Haven, CT; Department of Emergency Medicine (O.A.), Department of Radiology (A.V.), Gardner Neuroscience Institute (O.A., A.V.), Department of Neurology & Rehabilitation Medicine (D.W.), and Comprehensive Stroke Center (D.W.), University of Cincinnati, OH; Barrow Neurological Institute (F.-D.S.), Phoenix, AZ; Department of Neurology (S.J.K.), Baltimore Veterans Administration Medical Center, University of Maryland; Division of Public Health Sciences, Department of Biostatistical Sciences (C.L.), Wake Forest University School of Medicine, Winston-Salem, NC; and Center for Public Health Genomics (C.L.), University of Virginia, Charlottesville.
Daniel WooFrom the Division of Neurocritical Care and Emergency Neurology, Department of Neurology (L.C.M., G.J.F., A.L., K.N.S.), Yale School of Medicine, New Haven, CT; Department of Emergency Medicine (O.A.), Department of Radiology (A.V.), Gardner Neuroscience Institute (O.A., A.V.), Department of Neurology & Rehabilitation Medicine (D.W.), and Comprehensive Stroke Center (D.W.), University of Cincinnati, OH; Barrow Neurological Institute (F.-D.S.), Phoenix, AZ; Department of Neurology (S.J.K.), Baltimore Veterans Administration Medical Center, University of Maryland; Division of Public Health Sciences, Department of Biostatistical Sciences (C.L.), Wake Forest University School of Medicine, Winston-Salem, NC; and Center for Public Health Genomics (C.L.), University of Virginia, Charlottesville. woodl@ucmail.uc.edu.
University of Maryland, Baltimore · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9M
Ethnic/Racial Variation in Intracerebral Hemorrhage (ERICH)U01NS069763 · NINDS · UNIVERSITY OF CINCINNATI · PI ANDERSON, CHRISTOPHER DAVID, DEMEL, STACIE · 2010 to 2024
$34.2M
Intensive Blood Pressure Reduction in Deep Intracerebral HemorrhageR03NS112859 · NINDS · YALE UNIVERSITY · PI FALCONE, GUIDO JOSE, SHETH, KEVIN NAVIN · 2019 to 2020
$84k
NCATS NIH HHS UL1 TR001863NIA NIH HHS K76 AG059992NIA NIH HHS P30 AG021342NINDS NIH HHS R03 NS112859NINDS NIH HHS U01 NS069763
6 · The paper itself

Abstract

objectivesWe investigated the predictors of functional outcome in young patients enrolled in a multiethnic study of intracerebral hemorrhage (ICH).

methodsThe Ethnic/Racial Variations in Intracerebral Hemorrhage (ERICH) study is a prospective multicenter study of ICH among adult (age ≥18 years) non-Hispanic white, non-Hispanic black, and Hispanic participants. The study recruited 1,000 participants per racial/ethnic group. The present study utilized the subset of ERICH participants aged <50 years with supratentorial ICH. Functional outcome was ascertained using the modified Rankin Scale (mRS) at 3 months. Logistic regression was used to identify factors associated with poor outcome (mRS 4-6), and analyses were compared by race/ethnicity to identify differences across these groups.

resultsOf the 3,000 patients with ICH enrolled in ERICH, 418 were studied (mean age 43 years, 69% male), of whom 48 (12%) were white, 173 (41%) were black, and 197 (47%) were Hispanic. For supratentorial ICH, black participants (odds ratio [OR], 0.42;

conclusionsIn young patients with supratentorial ICH, black and Hispanic race/ethnicity is associated with better functional outcomes, compared with white race. Additional studies are needed to identify the biological and social mediators of this association.

Indexed as

Recovery of FunctionAdultBlack or African AmericanCerebral HemorrhageEthnicityFemaleHispanic or LatinoHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesRace FactorsWhite PeopleYoung Adult

Identifiers

PMID31969467
PMCPMC7274930
OpenAlexW3000915815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.