Evidence map›Paper›PMID 31969437›Full record

ArticleJournal of virology2020

Kaposi's Sarcoma-Associated Herpesvirus Infection Induces the Expression of Neuroendocrine Genes in Endothelial Cells.

Mohanan Valiya Veettil, Gayathri Krishna, Arunava Roy, Anandita Ghosh, Dipanjan Dutta, Binod Kumar, Sayan Chakraborty, Thoppil Raveendran Anju, Neelam Sharma-Walia, Bala Chandran

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
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  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Human cytomegalovirus induces neuronal enolase to support virally mediated metabolic remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Mohanan Valiya VeettilDepartment of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, India Mohanan.veettil@cusat.ac.in chandran@health.usf.edu.
Gayathri KrishnaDepartment of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, India.
Arunava RoyDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Anandita GhoshDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Dipanjan DuttaDepartment of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.
Binod KumarDepartment of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.ORCID 0000-0002-2077-8501
Sayan ChakrabortyInstitute of Molecular and Cell Biology A-STAR, Singapore.
Thoppil Raveendran AnjuDepartment of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, India.
Neelam Sharma-WaliaDepartment of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.
Bala ChandranDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA Mohanan.veettil@cusat.ac.in chandran@health.usf.edu.
Cochin University of Science and Technology · INRosalind Franklin University of Medicine and Science · USUniversity of South Florida · USAgency for Science, Technology and Research · SG

Funding

KSHV interactions with host nuclear innate response componentsR01CA180758 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI CHANDRAN, BALA · 2014 to 2023
$3.4M
NCI NIH HHS R01 CA180758
6 · The paper itself

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is etiologically associated with endothelial Kaposi's sarcoma (KS) in immunocompromised individuals. KS lesion cells exhibit many similarities to neuroendocrine (NE) cancers, such as highly vascular and red/purple tumor lesions, spindle-shaped cells, an insignificant role for classic oncogenes in tumor development, the release of bioactive amines, and indolent growth of the tumors. However, the mechanistic basis for the similarity of KS lesion endothelial cells to neuroendocrine tumors remains unknown. Next-generation sequencing and bioinformatics analysis in the present study demonstrate that endothelial cells latently infected with KSHV express several neuronal and NE genes.

Indexed as

Gene Expression Regulation, NeoplasticCarcinoma, NeuroendocrineCell LineCell ProliferationEndothelial CellsGene Expression Regulation, ViralGene Knockout TechniquesHerpesviridae InfectionsHerpesvirus 8, HumanHumansOpen Reading FramesPeptide HormonesPhosphopyruvate HydrataseRE1-Silencing Transcription FactorReceptors, HistamineReceptors, SomatostatinADM2 protein, humankaposin B protein, Human herpesvirus 8Peptide HormonesPhosphopyruvate HydrataseRE1-Silencing Transcription FactorReceptors, HistamineReceptors, SomatostatinRepressor Proteinssomatostatin receptor type 1Ubiquitin ThiolesteraseUCHL1 protein, humanViral Proteinscell proliferationendothelial cellsKaposi’s sarcoma-associated herpesvirusneuroendocrine genes

Identifiers

PMID31969437
PMCPMC7108831
OpenAlexW3000758280

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.