Evidence map›Paper›PMID 31969373›Full record

ArticleCancer research2020

A Prospective Analysis of Circulating Plasma Metabolites Associated with Ovarian Cancer Risk.

Oana A Zeleznik, A Heather Eliassen, Peter Kraft, Elizabeth M Poole, Bernard A Rosner, Sarah Jeanfavre, Amy A Deik, Kevin Bullock, Daniel S Hitchcock, Julian Avila-Pacheco and 2 more

Open access · greenAbstract read
In one paragraph

Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
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  5. Review
  6. Review
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  11. Review
  12. History of Breastfeeding in Relation to Circulating Inflammatory and Metabolic Biomarkers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  13. Article
  14. Article
  15. Plasma and ovarian metabolomic responses to chronic stress in female mice.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Oana A ZeleznikChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-8705-1163
A Heather EliassenChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Peter KraftDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Elizabeth M PooleChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Bernard A RosnerChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Sarah JeanfavreBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.
Amy A DeikBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.ORCID 0000-0002-9687-0953
Kevin BullockBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.
Daniel S HitchcockBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.
Julian Avila-PachecoBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.
Clary B Clish *Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.
Shelley S Tworoger *Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Shelley.Tworoger@moffitt.org.ORCID 0000-0002-6986-7046
Broad Institute · USBrigham and Women's Hospital · USHarvard University · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
NCI NIH HHS P01 CA087969NCI NIH HHS U01 CA176726NCI NIH HHS UM1 CA186107NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

Ovarian cancer has few known risk factors, hampering identification of high-risk women. We assessed the association of prediagnostic plasma metabolites (

Indexed as

AdultAgedBiomarkers, TumorCarcinoma, Ovarian EpithelialCase-Control StudiesFemaleFollow-Up StudiesGene Expression ProfilingHumansMetabolomicsMiddle AgedOvarian NeoplasmsProspective StudiesPseudouridineRisk AssessmentRisk FactorsBiomarkers, TumorPseudouridineTriglycerides

Identifiers

PMID31969373
PMCPMC7073287
OpenAlexW3001549748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.