Evidence map›Paper›PMID 31969136›Full record

Trial reportBMC public health2020

Effect of a family and interdisciplinary intervention to prevent T2D: randomized clinical trial.

Katya Vargas-Ortiz, Georgina Lira-Mendiola, Claudia M Gómez-Navarro, Katya Padilla-Estrada, Fabiola Angulo-Romero, José M Hernández-Márquez, Ana K Villa-Martínez, Jessica N González-Mena, Maciste H Macías-Cervantes, Maria de Lourdes Reyes-Escogido and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Katya Vargas-OrtizDepartment of Medical Sciences, University of Guanajuato, Campus León, Guanajuato, Mexico.
Georgina Lira-MendiolaMetabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
Claudia M Gómez-NavarroMetabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
Katya Padilla-EstradaMetabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
Fabiola Angulo-RomeroMetabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
José M Hernández-MárquezMetabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
Ana K Villa-MartínezMetabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
Jessica N González-MenaMetabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
Maciste H Macías-CervantesDepartment of Medical Sciences, University of Guanajuato, Campus León, Guanajuato, Mexico.
Maria de Lourdes Reyes-EscogidoMetabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
Rodolfo Guardado-MendozaMetabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico. rguardado@ugto.mx.ORCID http://orcid.org/0000-0003-3779-5575
Universidad de Guanajuato · MX

Funding

Consejo Nacional de Ciencia y Tecnología 202545/2013
6 · The paper itself

Abstract

backgroundLifestyle changes can reduce the risk of T2D; however, no study has evaluated the effect of a lifestyle intervention involving patients´ family. The aim of this study was to compare the impact of an interdisciplinary family (FI) Vs individual intervention (II) on glucose metabolism, insulin resistance (IR), pancreatic β-cell function and cardiovascular risk markers in patients with prediabetes, as well as to measure the impact on their families' metabolic risk.

methodsRandomized Clinical Trial (RCT) to compare the impact of FI and II on IR and pancreatic β-cell function in subjects with prediabetes. There were 122 subjects with prediabetes (and 101 family members) randomized to FI or II. Data were collected in 2015-2016 and analyzed in 2017-2018. FI group had the support of their family members, who also received personalized diet and exercise recommendations; patients and their family members attended monthly a lifestyle enhancement program. II group received personalized diet and exercise recommendations. The follow-up was for 12 months. Glucose, IR, pancreatic β-cell function and secondary outcomes (body composition and lipid profile) were assessed at baseline, 6 and 12 months.

resultsFI group improved area under the glucose curve (AUC) (from 18,597 ± 2611 to 17,237 ± 2792, p = 0.004) and the Matsuda index (from 3.5 ± 2.3 to 4.7 ± 3.5, p = 0.05) at 12 months. II group improved Disposition Index (from 1.5 ± 0.4 to 1.9 ± 0.73, p < .0001) at 12 months. The improvements achieved in weight and lipids at 6 months, were lost in II group at 12 moths, whereas in FI persisted. Adherence up to 12 months was not different between the study groups (FI 56% Vs II 60%).

conclusionsFI intervention was more effective by improving glucose AUC, insulin sensitivity and lipid profile, besides that, metabolic risk in family members of the FI group was maintained, while the risk of II group was increased.

trial registrationThis study was retrospectively registered at clinicaltrials.gov on December 15, 2015 (NTC026365646).

Indexed as

FamilyLife StyleAdolescentAdultBiomarkersBlood GlucoseDiabetes Mellitus, Type 2DietExerciseFemaleHumansInsulin ResistanceInsulin-Secreting CellsMaleMiddle AgedPatient Education as TopicBiomarkersBlood GlucoseFamily supportInterdisciplinaryInterventionPrediabetesPrevention

Identifiers

PMID31969136
PMCPMC6977289
OpenAlexW3007047425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.