Evidence map›Paper›PMID 31969053›Full record

ArticleCirculation research2020

Brain Damage With Heart Failure: Cardiac Biomarker Alterations and Gray Matter Decline.

Karsten Mueller, Friederike Thiel, Frank Beutner, Andrej Teren, Stefan Frisch, Tommaso Ballarini, Harald E Möller, Kristin Ihle, Joachim Thiery, Gerhard Schuler and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.

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  15. Relationship between cardiac index and brain volume in the UK Biobank.Cerebral circulation - cognition and behavior · 2026
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Karsten MuellerFrom the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.).
Friederike ThielFrom the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.).
Frank BeutnerLeipzig Heart Center, Germany (F.B., A.T., G.S.).
Andrej TerenLeipzig Heart Center, Germany (F.B., A.T., G.S.).
Stefan FrischFrom the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.).
Tommaso BallariniFrom the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.).
Harald E MöllerFrom the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.).
Kristin IhleFrom the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.).
Joachim ThieryLeipzig Heart Center, Germany (F.B., A.T., G.S.).
Gerhard SchulerLeipzig Heart Center, Germany (F.B., A.T., G.S.).
Arno VillringerFrom the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.).
Matthias L SchroeterFrom the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.).
Max Planck Institute for Human Cognitive and Brain Sciences · DELeipzig Heart Institute · DEUniversity Hospital Leipzig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleHeart failure (HF) following heart damage leads to a decreased blood flow due to a reduced pump efficiency of the heart muscle. A consequence can be insufficient oxygen supply to the organism including the brain. While HF clearly shows neurological symptoms, such as fatigue, nausea, and dizziness, the implications for brain structure are not well understood. Few studies show regional gray matter decrease related to HF; however, the underlying mechanisms leading to the observed brain changes remain unclear.

objectiveTo study the relationship between impaired heart function, hampered blood circulation, and structural brain change in a case-control study. METHODS AND

resultsWithin a group of 80 patients of the Leipzig Heart Center, we investigated a potential correlation between HF biomarkers and the brain's gray matter density (GMD) obtained by magnetic resonance imaging. We observed a significant positive correlation between cardiac ejection fraction and GMD across the whole frontal and parietal medial cortex reflecting the consequence of HF onto the brain's gray matter. Moreover, we also obtained a relationship between GMD and the NT-proBNP (N-terminal prohormone of brain natriuretic peptide)-a biomarker that is used for screening, diagnosis, and prognosis of HF. Here, we found a significant negative correlation between NT-proBNP and GMD in the medial and posterior cingulate cortex but also in precuneus and hippocampus, which are key regions implicated in structural brain changes in dementia.

conclusionsWe obtained significant correlations between brain structure and markers of heart failure including ejection fraction and NT-proBNP. A diminished GMD was found with decreased ejection fraction and increased NT-proBNP in wide brain regions including the whole frontomedian cortex as well as hippocampus and precuneus. Our observations might reflect structural brain damage in areas that are related to cognition; however, whether these structural changes facilitate the development of cognitive alterations has to be proven by further longitudinal studies.

Indexed as

AgedBiomarkersBrain Damage, ChronicCardiac OutputFemaleGray MatterHeart FailureHumansMaleMiddle AgedNatriuretic Peptide, BrainParietal LobeBiomarkersNatriuretic Peptide, Brainbrain imagingcoronary artery diseasegray matterheart failuremagnetic resonance imaging

Identifiers

PMID31969053
PMCPMC7077969
OpenAlexW2981512785

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.