ArticleNeurorehabilitation and neural repair2020
Vagus Nerve Stimulation Paired With Rehabilitative Training Enhances Motor Recovery After Bilateral Spinal Cord Injury to Cervical Forelimb Motor Pools.
Article in Neurorehabilitation and neural repair, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04534556 (Wireless Nerve Stimulation Device To Enhance Recovery After Stroke), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Wireless Nerve Stimulation Device To Enhance Recovery After Stroke
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Neurorehabilitation with vagus nerve stimulation: a systematic review.Frontiers in neurology · 2024Pooled it
- At-Home Delivery of Vagus Nerve Stimulation Paired With Task-Specific Training Improves Performance of High-Priority Activities in Persons With Chronic Spinal Cord Injury or Stroke.American journal of physical medicine & rehabilitation · 2026Trial
- Safety and feasibility of paired vagus nerve stimulation with rehabilitation for improving upper extremity function in people with cervical spinal cord injury: a pilot randomized controlled trial.Frontiers in rehabilitation sciences · 2026Trial
- Trial
- Auricular Vagus Nerve Stimulation Combined with Physical Therapy for Individuals with Parkinson's Disease: A Pilot Randomized Sham-Controlled Trial.Neurology international · 2026Article
- Enhancing Neuroplasticity via vagus nerve stimulation to improve urinary dysfunction after spinal cord injury: a perspective.Bioelectronic medicine · 2025Review
- Closed-loop Neuromotor Training System Pairing Transcutaneous Vagus Nerve Stimulation with Video-based Real-time Movement Classification.medRxiv : the preprint server for health sciences · 2025Article
- Advice for translational neuroscience: move deliberately and build things.Bioelectronic medicine · 2025Article
- Recent Trends in Physical Therapy Interventions and Neuromodulation Techniques to Improve Neurorehabilitation.CNS & neurological disorders drug targets · 2025Review
- Non-invasive vagus nerve stimulation is associated with the reduction in persistent post-concussion symptoms: an observational study.Frontiers in neurology · 2025Article
- Recent Trends in Physical Therapy Interventions and Neuromodulation Techniques to Improve Neurorehabilitation.CNS & neurological disorders drug targets · 2025Review
- Characterization of an Algorithm for Autonomous, Closed-Loop Neuromodulation During Motor Rehabilitation.Neurorehabilitation and neural repair · 2024Article
- Article
- Safety and feasibility of paired vagus nerve stimulation with rehabilitation for improving upper extremity function in people with cervical spinal cord injury: study protocol for a pilot randomized controlled trial.Frontiers in neurology · 2024Article
- Importance of timing optimization for closed-loop applications of vagus nerve stimulation.Bioelectronic medicine · 2023Review
- Narrative review of current neuromodulation modalities for spinal cord injury.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- A review of combined neuromodulation and physical therapy interventions for enhanced neurorehabilitation.Frontiers in human neuroscience · 2023Review
- Clinical Research Progress of the Post-Stroke Upper Limb Motor Function Improvement via Transcutaneous Auricular Vagus Nerve Stimulation.Neural plasticity · 2023Review
- Natural and targeted circuit reorganization after spinal cord injury.Nature neuroscience · 2022Review
- Timing of vagus nerve stimulation during fear extinction determines efficacy in a rat model of PTSD.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Closed-loop vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a strategy to enhance recovery after neurological injury. Previous studies demonstrate that brief bursts of closed-loop VNS paired with rehabilitative training substantially improve recovery of forelimb motor function in models of unilateral and bilateral contusive spinal cord injury (SCI) at spinal level C5/6. While these findings provide initial evidence of the utility of VNS for SCI, the injury model used in these studies spares the majority of alpha motor neurons originating in C7-T1 that innervate distal forelimb muscles. Because the clinical manifestation of SCI in many patients involves damage at these levels, it is important to define whether damage to the distal forelimb motor neuron pools limits VNS-dependent recovery. In this study, we assessed recovery of forelimb function in rats that received a bilateral incomplete contusive SCI at C7/8 and underwent extensive rehabilitative training with or without paired VNS. The study design, including planned sample size, assessments, and statistical comparisons, was preregistered prior to beginning data collection ( https://osf.io/ysvgf/ ). VNS paired with rehabilitative training significantly improved recovery of volitional forelimb strength compared to equivalent rehabilitative training without VNS. Additionally, VNS-dependent enhancement of recovery generalized to 2 similar, but untrained, forelimb tasks. These findings indicate that damage to alpha motor neurons does not prevent VNS-dependent enhancement of recovery and provides additional evidence to support the evaluation of closed-loop VNS paired with rehabilitation in patients with incomplete cervical SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.