Evidence map›Paper›PMID 31968684›Full record

ArticleViruses2020

Identification of A Novel Papillomavirus Associated with Squamous Cell Carcinoma in A Domestic Cat.

Maura Carrai, Kate Van Brussel, Mang Shi, Ci-Xiu Li, Wei-Shan Chang, John S Munday, Katja Voss, Alicia McLuckie, David Taylor, Andrew Laws and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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  7. Canine and feline papillomaviruses: an update.Frontiers in veterinary science · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Maura CarraiSydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney NSW 2006, Australia.
Kate Van BrusselSydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney NSW 2006, Australia.
Mang ShiSchool of Life and Environmental Sciences and School of Medical Sciences, University of Sydney, Sydney NSW 2006, Australia.
Ci-Xiu LiSchool of Life and Environmental Sciences and School of Medical Sciences, University of Sydney, Sydney NSW 2006, Australia.
Wei-Shan ChangSchool of Life and Environmental Sciences and School of Medical Sciences, University of Sydney, Sydney NSW 2006, Australia.ORCID 0000-0003-0991-6827
John S Munday.School of Veterinary Science, Massey University, Palmerston North 4410, New Zealand.
Katja VossSydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney NSW 2006, Australia.
Alicia McLuckieSydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney NSW 2006, Australia.
David TaylorVetnostics, 60 Waterloo Rd, North Ryde NSW 2113, Australia.
Andrew LawsWentworth Falls Animals Hospital, 1/295-297 Great Western Highway, Wentworth Falls NSW 2782, Australia.
Edward C HolmesSchool of Life and Environmental Sciences and School of Medical Sciences, University of Sydney, Sydney NSW 2006, Australia.
Vanessa R BarrsSydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney NSW 2006, Australia.
Julia A BeattySydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney NSW 2006, Australia.
The University of Sydney · AUMassey University · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Papillomaviruses infect the skin and mucosal surfaces of diverse animal hosts with consequences ranging from asymptomatic colonization to highly malignant epithelial cancers. Increasing evidence suggests a role for papillomaviruses in the most common cutaneous malignancy of domestic cats, squamous cell carcinoma (SCC). Using total DNA sequencing we identified a novel feline papillomavirus in a nasal biopsy taken from a cat presenting with both nasal cavity lymphoma and recurrent squamous cell carcinoma affecting the nasal planum. We designate this novel virus as Felis catus papillomavirus 6 (FcaPV6). The complete FcaPV6 7453 bp genome was similar to those of other feline papillomaviruses and phylogenetic analysis revealed that it was most closely related to FcaPV3, although was distinct enough to represent a new viral type. Classification of FcaPV6 in a new genus alongside FcaPVs 3, 4 and 5 is supported. Archived excisional biopsy of the SCC, taken 20 months prior to presentation, was intensely positive on p16 immunostaining. FcaPV6, amplified using virus-specific, but not consensus, PCR, was the only papillomavirus detected in DNA extracted from the SCC. Conversely, renal lymphoma, sampled at necropsy two months after presentation, tested negative on FcaPV6-specific PCR. In sum, using metagenomics we demonstrate the presence of a novel feline papillomavirus in association with cutaneous squamous cell carcinoma.

Indexed as

AnimalsCarcinoma, Squamous CellCat DiseasesCatsDNA, ViralGenome, ViralMaleNeoplasm Recurrence, LocalPapillomaviridaePapillomavirus InfectionsPhylogenySequence Analysis, DNASkinSkin NeoplasmsDNA, Viralcancercatdiscoveryfelidfelineoncogenicpapillomaviruspathogenphylogenysquamous cell carcinoma

Identifiers

PMID31968684
PMCPMC7019393
OpenAlexW2995932121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.