Evidence map›Paper›PMID 31968678›Full record

ArticleCancers2020

Survival-Associated Metabolic Genes in Human Papillomavirus-Positive Head and Neck Cancers.

Martin A Prusinkiewicz, Steven F Gameiro, Farhad Ghasemi, Mackenzie J Dodge, Peter Y F Zeng, Hanna Maekebay, John W Barrett, Anthony C Nichols, Joe S Mymryk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Martin A PrusinkiewiczDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON N6A 3K7, Canada.ORCID 0000-0001-8310-7855
Steven F GameiroDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON N6A 3K7, Canada.
Farhad GhasemiDepartment of Surgery, The University of Western Ontario, London, ON N6A 3K7, Canada.
Mackenzie J DodgeDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON N6A 3K7, Canada.
Peter Y F ZengDepartment of Otolaryngology, Head & Neck Surgery, The University of Western Ontario, London, ON N6A 3K7, Canada.
Hanna MaekebayDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON N6A 3K7, Canada.
John W BarrettDepartment of Otolaryngology, Head & Neck Surgery, The University of Western Ontario, London, ON N6A 3K7, Canada.
Anthony C NicholsDepartment of Otolaryngology, Head & Neck Surgery, The University of Western Ontario, London, ON N6A 3K7, Canada.ORCID 0000-0002-0760-980X
Joe S MymrykDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON N6A 3K7, Canada.ORCID 0000-0002-3521-8005

Funding

Canadian Institutes of Health Research MOP#148689Canadian Institutes of Health Research MOP#340674
6 · The paper itself

Abstract

Human papillomavirus (HPV) causes an increasing number of head and neck squamous cell carcinomas (HNSCCs). Altered metabolism contributes to patient prognosis, but the impact of HPV status on HNSCC metabolism remains relatively uncharacterized. We hypothesize that metabolism-related gene expression differences unique to HPV-positive HNSCC influences patient survival. The Cancer Genome Atlas RNA-seq data from primary HNSCC patient samples were categorized as 73 HPV-positive, 442 HPV-negative, and 43 normal-adjacent control tissues. We analyzed 229 metabolic genes and identified numerous differentially expressed genes between HPV-positive and negative HNSCC patients. HPV-positive carcinomas exhibited lower expression levels of genes involved in glycolysis and higher levels of genes involved in the tricarboxylic acid cycle, oxidative phosphorylation, and β-oxidation than the HPV-negative carcinomas. Importantly, reduced expression of the metabolism-related genes

Indexed as

cancer metabolismcellular respirationglycolysishead and neck cancerhuman papillomavirusTCGA

Identifiers

PMID31968678
PMCPMC7017314

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.