Evidence map›Paper›PMID 31968581›Full record

ArticleInternational journal of molecular sciences2020

Age-Induced Differential Changes in the Central and Colonic Human Circadian Oscillators.

Cristina Camello-Almaraz, Francisco E Martin-Cano, Francisco J Santos, Mª Teresa Espin, Juan Antonio Madrid, Maria J Pozo, Pedro J Camello

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Analysis of Circadian Clock Gene Expression in Human Skin Explants.JID innovations : skin science from molecules to population health · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Cristina Camello-AlmarazDepartment of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, Campus Universitario, 10003 Cáceres, Spain.
Francisco E Martin-CanoDepartment of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, Campus Universitario, 10003 Cáceres, Spain.
Francisco J SantosSurgery Department, University Hospital, Servicio Extremeño de Salud, Avda Universidad, 10004 Cáceres, Spain.
Mª Teresa EspinFaculty of Medicine, Infanta Cristina University Hospital, Servicio Extremeño de Salud, Avda Elbas, 06080 Badajoz, Spain.
Juan Antonio MadridChronobiology Lab, Department of Physiology, College of Biology, University of Murcia, Mare Nostrum Campus, IMIB-Arrixaca, 30100 Murcia, Spain.
Maria J PozoDepartment of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, Campus Universitario, 10003 Cáceres, Spain.
Pedro J CamelloDepartment of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, Campus Universitario, 10003 Cáceres, Spain.ORCID 0000-0001-5026-7166
Universidad de Extremadura · ESHospital Universitario Infanta Cristina · ESUniversidad de Murcia · ES

Funding

Junta de Extremadura, Plan Regional de Investigación IB18025Ministerio de Ciencia e Innovación BFU2011-24365
6 · The paper itself

Abstract

Aging modifies not only multiple cellular and homeostatic systems, but also biological rhythms. The circadian system is driven by a central hypothalamic oscillator which entrains peripheral oscillators, in both cases underlain by circadian genes. Our aim was to characterize the effect of aging in the circadian expression of clock genes in the human colon. Ambulatory recordings of the circadian rhythms of skin wrist temperature, motor activity and the integrated variable TAP (temperature, activity and position) were dampened by aging, especially beyond 74 years of age. On the contrary, quantitative analysis of genes expression in the muscle layer of colonic explants during 24 h revealed that the circadian expression of

Indexed as

AgingCircadian RhythmAdultAgedAged, 80 and overBiological ClocksBiomarkersCalcium SignalingCLOCK ProteinsColonGene Expression RegulationHumansMiddle AgedMuscle ContractionMuscle, SmoothBiomarkersCLOCK Proteinscalcium signalscircadian rhythmsclock genescoloncontractilitysmooth muscle

Identifiers

PMID31968581
PMCPMC7013976
OpenAlexW2999541856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.