Trial reportNutrients2020
Circulating Ionized Magnesium: Comparisons with Circulating Total Magnesium and the Response to Magnesium Supplementation in a Randomized Controlled Trial.
Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review.Nutrients · 2021Pooled it
- Randomized, open-label study of the short-term pharmacokinetics of oral magnesium oxide in healthy volunteers.Scientific reports · 2026Trial
- The effect of oral magnesium supplementation on glycemic control and metabolic parameters in type 2 diabetes mellitus: a double-blind randomized controlled trial.Frontiers in endocrinology · 2026Trial
- Relationship between short-term self-reported dietary magnesium intake and whole blood ionized magnesium (iMgAnnals of medicine · 2023Trial
- Clinical trial on the effects of oral magnesium supplementation in stable-phase COPD patients.Aging clinical and experimental research · 2022Trial
- Circulating Ionized Magnesium as a Measure of Supplement Bioavailability: Results from a Pilot Study for Randomized Clinical Trial.Nutrients · 2020Trial
- Dysmagnesemia in the ICU: A Comparative Analysis of Ionized and Total Magnesium Levels and Their Clinical Associations.Metabolites · 2025Article
- Ionized and total magnesium levels and health outcomes in patients with type 2 diabetes mellitus.Scientific reports · 2025Article
- Prevalence, clinical characteristics, and health outcomes of dysmagnesemia measured by ionized and total body concentrations among medically hospitalized patients.Scientific reports · 2024Article
- Article
- Magnesium matters: unveiling hidden risks in kidney transplant patients through total and ionized magnesium profiling.Frontiers in nephrology · 2024Article
- The Stability of Analytes of Ionized Magnesium Concentration and Its Reference Range in Healthy Volunteers.Biomedicines · 2023Article
- Magnesium Deficiency and Cardiometabolic Disease.Nutrients · 2023Review
- Article
- Early Plasma Magnesium in Near-Term and Term Infants with Neonatal Encephalopathy in the Context of Perinatal Asphyxia.Children (Basel, Switzerland) · 2022Article
- Does Ionized Magnesium Offer a Different Perspective Exploring the Association between Magnesemia and Targeted Cardiovascular Risk Factors?Journal of clinical medicine · 2022Article
- Article
- Two Cases of Liver Transplantation With a High Ionized Magnesium to Total Magnesium Ratio.Cureus · 2022Article
- Association between ionized magnesium and postoperative shivering.Journal of anesthesia · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Ionized Mg (iMg) is considered the biologically active fraction of circulating total Mg (tMg). It is possible that iMg may be a more physiologically relevant marker than tMg. Using data from a double-blind pilot randomized controlled trial, we tested (1) whether oral Mg supplementation will increase iMg concentrations compared with placebo and (2) the relationship between iMg and tMg at baseline. Additionally, we evaluated the agreement between iMg measured in fresh whole blood versus stored samples. A total of fifty-nine participants were randomized 1:1 to oral Mg supplementation (400 mg/day, Mg Oxide) or placebo for 10 weeks. Fasting blood samples were obtained at baseline and follow-up. The analysis used linear regression and an intent-to-treat approach. Participants were generally healthy, the mean age was 62, and 73% were female. The baseline iMg and tMg were modestly and positively associated (r = 0.50). The ratio of baseline iMg to tMg was 64%. The mean supplement effect on iMg was 0.03 mmol/L (95% CI:0.01, 0.05) for Mg supplementation versus placebo. The supplement effect on iMg was not statistically significantly different according to baseline iMg status (above/below median). Compared to fresh blood, iMg was consistently higher in refrigerated and frozen samples by 0.14 and 0.20 mmol/L, respectively. In this relatively healthy adult population, Mg supplementation over 10 weeks resulted in increased iMg concentrations. Whether iMg is a more appropriate measure of Mg status than tMg, and the public health or clinical utility of measuring iMg remains to be determined.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.