ArticleCell reports2020
Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06094504 (Impact of Full Spectrum Light on Outcomes of Infants With Intestinal Failure), which is not on this map. Cited by 66 papers.
0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT06094504 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation
Impact of Full Spectrum Light on Outcomes of Infants With Intestinal Failure
Who cites it
66 citing papers in PubMed, 96 citations in OpenAlex.
- A non-invasive method for light-inducible knockout across all cell types in mouse subcutaneous adipose tissue.Adipocyte · 2026Article
- Prevention of myopia in a near-primate by supplemental indigo light suggests a hypothesis for the myopia boom.Cell reports. Medicine · 2026Article
- Opposing Roles of OPN3 and OPN5 Affecting the Intrinsic Pupillary Light Reflex of the Mammalian Iris.Investigative ophthalmology & visual science · 2026Article
- Review
- Light and myopia: a focus on the expanding role of non-visual opsins.Eye and vision (London, England) · 2026Review
- Opn3 Drives Blue-Light-Induced Reduction in Lipid Droplets and Antiviral Defense.Biomolecules · 2026Article
- Non-visual opsins and their role in circadian photoentrainment.Eye and vision (London, England) · 2026Review
- Optogenetic Cancer Therapy Using the Light-Driven Outward Proton Pump Rhodopsin Archaerhodopsin-3 (AR3).Journal of the American Chemical Society · 2025Article
- The physiological functions of OPN5m.Eye and vision (London, England) · 2025Review
- Effect of external cues on clock-driven protection from influenza A infection.The Journal of clinical investigation · 2025Article
- Validation of phiC31-mediated expression and functional knockout of Opn3 in the Opn3-phiC31o knock-in mouse.Eye and vision (London, England) · 2025Article
- Article
- Roles of sensory receptors in non-sensory organs: the kidney and beyond.Nature reviews. Nephrology · 2025Review
- Neuropsin, TRPV4 and intracellular calcium mediate intrinsic photosensitivity in corneal epithelial cells.The ocular surface · 2025Article
- β-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Opposing expression pattern of opsin 3 and opsin 5 in the developing and adult nasal epithelium.Chemical senses · 2025Article
- The widely used Ucp1-Cre transgene elicits complex developmental and metabolic phenotypes.Nature communications · 2025Article
- Light does not phase shift the circadian clock of subcutaneous adipose tissue in vitro.Npj biological timing and sleep · 2025Article
- Role of visual and non-visual opsins in blue light-induced neurodegeneration inFrontiers in public health · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 5 institutions in 2 countries.
Gowri NayakCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Kevin X ZhangCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Shruti VemarajuCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Yoshinobu OdakaCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Ethan D BuhrDepartment of Ophthalmology, University of Washington Medical School, Seattle, WA 98104, USA.
Amanda Holt-JonesDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
Stace KernodleDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
April N SmithCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Brian A UptonCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Shane D'SouzaCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Jesse J ZhanCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Nicolás DiazDepartment of Ophthalmology, University of Washington Medical School, Seattle, WA 98104, USA.
Minh-Thanh NguyenCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Rajib MukherjeeDivision of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Shannon A GordonDepartment of Ophthalmology, University of Washington Medical School, Seattle, WA 98104, USA.
Gang WuCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Robert SchmidtCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Xue MeiCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Nathan T PettsDivision of Clinical Engineering, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Matthew BatieDivision of Clinical Engineering, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Sujata RaoThe Cleveland Clinic, Ophthalmic Research, 9500 Euclid Avenue, OH 44195, USA.
John B HogeneschCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Takahisa NakamuraDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA; Department of Metabolic Bioregulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi 980-8575, Japan.
Alison SweeneyDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
Randy J SeeleyDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Russell N Van GelderDepartment of Ophthalmology, University of Washington Medical School, Seattle, WA 98104, USA; Department of Biological Structure, University of Washington Medical School, Seattle, WA 98104, USA; Department of Pathology, University of Washington Medical School, Seattle, WA 98104, USA.
Joan Sanchez-GurmachesDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
Richard A LangCenter for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Ophthalmology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA. Electronic address: richard.lang@cchmc.org.
Cincinnati Children's Hospital Medical Center · USUniversity of Washington Medical Center · USUniversity of Michigan–Ann Arbor · USUniversity of Pennsylvania · USCleveland Clinic · US
Funding
Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI MAUREEN E NEITZ · 1985 to 2026
$23.5MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3MRESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI Brian D Perkins · 2016 to 2026
$7.7MMedical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7MFunctions of OPN5 and OPN3 in the eyeR01EY026921 · NEI · UNIVERSITY OF WASHINGTON · PI VAN GELDER, RUSSELL N., YAU, KING-WAI · 2017 to 2021
$2.8MRole of extracellular vesicles in the regulation of immunometabolism in obesityR01DK123181 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI NAKAMURA, TAKAHISA · 2020 to 2023
$2.7MRegulation of vascular development in the eye by an opsin 5-dependent clockR01EY027077 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A., RAO, SUJATA · 2016 to 2020
$2.4MRegulation of eye development by an Opsin5-dopamine pathwayR01EY027711 · NEI · EMORY UNIVERSITY · PI IUVONE, P MICHAEL, LANG, RICHARD A. · 2017 to 2020
$1.9MThe role of OPN5 in extraocular circadian photoentrainment in mammalsR01GM124246 · NIGMS · UNIVERSITY OF WASHINGTON · PI BUHR, ETHAN D · 2017 to 2021
$1.9MRole of Hepatic RNA Silencing in Insulin Resistance and ObesityR01DK107530 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI NAKAMURA, TAKAHISA · 2016 to 2020
$1.8MLight regulated vascular development in the eye via the Hippo pathwayR01EY032029 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A., XIN, MEI · 2021 to 2024
$1.6MAmerican Heart Association-American Stroke Association 18CDA34080527NEI NIH HHS P30 EY001730NEI NIH HHS P30 EY025585NEI NIH HHS R01 EY026921NEI NIH HHS R01 EY027077NEI NIH HHS R01 EY027711NEI NIH HHS R01 EY032029NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK107530NIDDK NIH HHS R01 DK123181NIGMS NIH HHS R01 GM124246NIGMS NIH HHS T32 GM063483
Abstract
Almost all life forms can detect and decode light information for adaptive advantage. Examples include the visual system, in which photoreceptor signals are processed into virtual images, and the circadian system, in which light entrains a physiological clock. Here we describe a light response pathway in mice that employs encephalopsin (OPN3, a 480 nm, blue-light-responsive opsin) to regulate the function of adipocytes. Germline null and adipocyte-specific conditional null mice show a light- and Opn3-dependent deficit in thermogenesis and become hypothermic upon cold exposure. We show that stimulating mouse adipocytes with blue light enhances the lipolysis response and, in particular, phosphorylation of hormone-sensitive lipase. This response is Opn3 dependent. These data establish a key mechanism in which light-dependent, local regulation of the lipolysis response in white adipocytes regulates energy metabolism.
Indexed as
LightAdipocytes, BrownAdipocytes, WhiteAnimalsCold TemperatureEnergy MetabolismGene Expression ProfilingLipolysisMice, Inbred C57BLPhenotypePhotonsRod OpsinsThermogenesisOPN3 protein, mouseRod OpsinsadipocyteencephalopsinlightlipolysismetabolismmitochondriaOPN3opsinthermogenesis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT06094504ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.