Evidence map›Paper›PMID 31968178›Full record

ArticleAmerican journal of respiratory and critical care medicine2020

mTORC1 in Pulmonary Arterial Hypertension. At the Crossroads between Vasoconstriction and Vascular Remodeling?

Elena A Goncharova, Marc A Simon, Jason X-J Yuan

Open access · hybridAbstract readEditorialComment
In one paragraph

Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. [Silencing DDX17 inhibits proliferation and migration of pulmonary arterial smooth muscle cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. New trends in pulmonary hypertension.European respiratory review : an official journal of the European Respiratory Society · 2023
    Article
  8. Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  9. TRPC6, a therapeutic target for pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Elena A GoncharovaPittsburgh Heart, Lung, and Blood Vascular Medicine InstituteUniversity of PittsburghPittsburgh, Pennsylvaniaand.ORCID 0000-0001-7118-6752
Marc A SimonPittsburgh Heart, Lung, and Blood Vascular Medicine InstituteUniversity of PittsburghPittsburgh, Pennsylvaniaand.
Jason X-J YuanDivision of Pulmonary, Critical Care, and Sleep MedicineUniversity of California, San DiegoLa Jolla, California.
University of Pittsburgh · USUniversity of California System · US

Funding

Vascular Subphenotypes of Lung DiseaseP01HL103455 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GLADWIN, MARK T · 2011 to 2020
$26.1M
Translational Training Program in Pulmonary Biology and MedicineT32HL007563 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Melanie Koenigshoff · 1985 to 2026
$12.3M
HIPPO Signaling in Pulmonary Arterial HypertensionR01HL130261 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GONCHAROVA, ELENA · 2016 to 2023
$3.5M
Phase II Trial of Metformin for Pulmonary Hypertension in Heart Failure with Preserved Ejection FractionR01AG058659 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIMON, MARC A · 2018 to 2022
$3.2M
TSC2 Signaling in Pulmonary Arterial HypertensionR01HL113178 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GONCHAROVA, ELENA · 2012 to 2021
$3.1M
NHLBI NIH HHS P01 HL103455NHLBI NIH HHS R01 HL113178NHLBI NIH HHS R01 HL130261NHLBI NIH HHS T32 HL007563NIA NIH HHS R01 AG058659
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Pulmonary Arterial HypertensionVascular RemodelingFamilial Primary Pulmonary HypertensionHumansMechanistic Target of Rapamycin Complex 1VasoconstrictionMechanistic Target of Rapamycin Complex 1

Identifiers

PMID31968178
PMCPMC7233339
OpenAlexW3003003290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.