ArticlePloS one2020
Knee joint distraction in regular care for treatment of knee osteoarthritis: A comparison with clinical trial data.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06458816 (The Utility of a Non-Invasive Distractor During Arthroscopy of the Knee Joint), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Utility of a Non-Invasive Distractor During Arthroscopy of the Knee Joint
Who cites it
26 citing papers in PubMed.
- Trial
- Evolving Strategies for Knee Osteoarthritis: A Narrative Review of Integrated Rehabilitation, Pharmacologic, and Joint-Preserving Interventions.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- [Knee joint distraction : A short narrative literature review].Orthopadie (Heidelberg, Germany) · 2026Review
- Article
- Recent Advances in Therapeutic Approaches for Knee Osteoarthritis: a Narrative Review.Biomolecules & therapeutics · 2026Review
- Delaying arthroplasty: The potential of knee joint distraction in young osteoarthritis patients-A prospective case series.Journal of experimental orthopaedics · 2025Article
- [Treatment of rheumatoid arthritis of wrist using Ilizarov wrist joint distraction technique: a case report].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Article
- Comparison of Clinical Efficacy and Mechanical Characteristics of Two Knee Distraction Devices With Relevance for Clinical Practice.Cartilage · 2024Article
- Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1.Arthritis research & therapy · 2024Article
- Artificial intelligence in osteoarthritis: repair by knee joint distraction shows association of pain, radiographic and immunological outcomes.Rheumatology (Oxford, England) · 2023Article
- Joint distraction using a purpose-built device for knee osteoarthritis: a prospective 2-year follow-up.RMD open · 2023Article
- Article
- Patients with advanced lateral osteoarthritis can return to sports and work after distraction arthroplasty plus lateral meniscal allograft transplantation combined with cartilage repair.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- Knee joint distraction results in MRI cartilage thickness increase up to 10 years after treatment.Rheumatology (Oxford, England) · 2022Article
- [No Evidence for the Biomechanical and Pathophysiological Explanatory Models of Musculoskeletal Diseases According to Liebscher & Bracht].Zeitschrift fur Orthopadie und Unfallchirurgie · 2022Article
- Intermittent Hydrostatic Pressure Promotes Cartilage Repair in an Inflammatory Environment through Hippo-YAP SignalingBioMed research international · 2022Article
- Joint distraction for osteoarthritis: clinical evidence and molecular mechanisms.Nature reviews. Rheumatology · 2022Review
- Role of joint distraction in osteoarthritis of the knee: Basic science, principles and outcomes.Journal of clinical orthopaedics and trauma · 2022Review
- Changes in Cartilage Thickness and Denuded Bone Area after Knee Joint Distraction and High Tibial Osteotomy-Post-Hoc Analyses of Two Randomized Controlled Trials.Journal of clinical medicine · 2021Article
- Comparison between 2D radiographic weight-bearing joint space width and 3D MRI non-weight-bearing cartilage thickness measures in the knee using non-weight-bearing 2D and 3D CT as an intermediary.Therapeutic advances in chronic disease · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesKnee joint distraction (KJD) has been evaluated as a joint-preserving treatment to postpone total knee arthroplasty in knee osteoarthritis patients in three clinical trials. Since 2014 the treatment is used in regular care in some hospitals, which might lead to a deviation from the original indication and decreased treatment outcome. In this study, baseline characteristics, complications and clinical benefit are compared between patients treated in regular care and in clinical trials.
methodsIn our hospital, 84 patients were treated in regular care for 6 weeks with KJD. Surgical details, complications, and range of motion were assessed from patient hospital charts. Patient-reported outcome measures were evaluated in regular care before and one year after treatment. Trial patients (n = 62) were treated and followed as described in literature.
resultsPatient characteristics were not significantly different between groups, except for distraction duration (regular care 45.3±4.3; clinical trials 48.1±8.1 days; p = 0.019). Pin tract infections were the most occurring complication (70% regular care; 66% clinical trials), but there was no significant difference in treatment complications between groups (p>0.1). The range of motion was recovered within a year after treatment for both groups. WOMAC questionnaires showed statistically and clinically significant improvement for both groups (both p<0.001 and >15 points in all subscales) and no significant differences between groups (all differences p>0.05). After one year, 70% of patients were responders (regular care 61%, trial 75%; p = 0.120). Neither regular care compared to clinical trial, nor any other characteristic could predict clinical response.
conclusionsKJD as joint-preserving treatment in clinical practice, to postpone arthroplasty for end-stage knee osteoarthritis patient below the age of 65, results in an outcome similar to that thus far demonstrated in clinical trials. Longer follow-up in regular care is needed to test whether also long-term results remain beneficial and comparable to trial data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.