Evidence map›Paper›PMID 31967856›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020

Synthetic apolipoprotein A-I mimetic peptide 4F protects hearts and kidneys after myocardial infarction.

Roberto S Moreira, Maria C Irigoyen, Jose M C Capcha, Talita R Sanches, Paulo S Gutierrez, Margoth R Garnica, Irene de L Noronha, Lucia Andrade

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. HDL and chronic kidney disease.Atherosclerosis plus · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Signaling pathways and targeted therapy for myocardial infarction.Signal transduction and targeted therapy · 2022
    Review
  8. HDL and Therapy.Advances in experimental medicine and biology · 2022
    Article
  9. HDL Mimetic Peptides.Advances in experimental medicine and biology · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Roberto S MoreiraDivision of Nephrology, University of São Paulo School of Medicine, São Paulo, Brazil.ORCID 0000-0002-7496-9178
Maria C IrigoyenLaboratory of Hypertension, Heart Institute, University of São Paulo School of Medicine, São Paulo, Brazil.
Jose M C CapchaDivision of Nephrology, University of São Paulo School of Medicine, São Paulo, Brazil.
Talita R SanchesDivision of Nephrology, University of São Paulo School of Medicine, São Paulo, Brazil.
Paulo S GutierrezLaboratory of Pathology, Heart Institute, University of São Paulo School of Medicine, São Paulo, Brazil.
Margoth R GarnicaDivision of Nephrology, University of São Paulo School of Medicine, São Paulo, Brazil.
Irene de L NoronhaDivision of Nephrology, University of São Paulo School of Medicine, São Paulo, Brazil.
Lucia AndradeDivision of Nephrology, University of São Paulo School of Medicine, São Paulo, Brazil.ORCID 0000-0002-3078-8957
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients undergoing coronary angiography after myocardial infarction (MI) often develop cardiac and renal dysfunction. We hypothesized that the apolipoprotein A-I mimetic peptide 4F (4F) would prevent those complications. Male Wistar rats were fed a high-cholesterol diet for 8 days. The rats were then anesthetized with isoflurane and randomly divided into five groups: a control group (sham-operated rats), and four groups of rats induced to MI by left coronary artery ligation, the rats in three of those groups being injected 6 h later, with the nonionic contrast agent iopamidol, 4F, and iopamidol plus 4F, respectively. At postprocedure

Indexed as

AnimalsCoronary VesselsHeartKidneyMaleMyocardial InfarctionMyocardiumNitric OxideNitric Oxide Synthase Type IIIRatsRats, WistarTriglyceridesVascular Endothelial Growth Factor ANitric OxideNitric Oxide Synthase Type IIITriglyceridesVascular Endothelial Growth Factor Aapolipoprotein Acontrast media/adverse effectshypercholesterolemiamyocardial infarctionpeptides

Identifiers

PMID31967856
PMCPMC7099456
OpenAlexW3002538151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.