ArticleJournal of clinical laboratory analysis2020
Plasma level of miR-99b may serve as potential diagnostic and short-term prognostic markers in patients with acute cerebral infarction.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Systematic review and meta-analysis of stroke blood biomarker data highlights need for more translational research methods.Nature communications · 2026Pooled it
- Circulating microRNAs in various etiopathogenetic subtypes of acute ischemic stroke: a human systematic review study.Frontiers in neurology · 2025Pooled it
- Circulating MicroRNAs and Extracellular Vesicle-Derived MicroRNAs as Predictors of Functional Recovery in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- The Role and Diagnostic Efficacy of the METTL14/GADD45B mCellular and molecular neurobiology · 2026Article
- Correlation of serum calprotectin with outcome of acute cerebral infarction.Open medicine (Warsaw, Poland) · 2025Article
- Considering Context-Specific microRNAs in Ischemic Stroke with Three "W": Where, When, and What.Molecular neurobiology · 2024Review
- Increasing serum miR-223-3p indicates the onset, severe development, and adverse prognosis of bronchiectasis: a retrospective study.BMC pulmonary medicine · 2024Article
- Neuroinflammation-associated miR-106a-5p serves as a biomarker for the diagnosis and prognosis of acute cerebral infarction.BMC neurology · 2023Article
- Acupuncture-Moxibustion Combined with Rehabilitation Training Is Conducive to Improving the Curative Effect, Cognitive Function, and Daily Activities of Patients with Cerebral Infarction.Computational and mathematical methods in medicine · 2022Article
- Plasma miR-409-3p promotes acute cerebral infarction via suppressing CTRP3.The Kaohsiung journal of medical sciences · 2021Article
- Plasma level of miR-99b may serve as potential diagnostic and short-term prognostic markers in patients with acute cerebral infarction.Journal of clinical laboratory analysis · 2020Article
- miR-124 Is Downregulated in Serum of Acute Cerebral Infarct Patients and Shows Diagnostic and Prognostic Value.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the present study is to explore the potential diagnostic and prognostic value of plasma levels of miR-99 family for patients with acute cerebral infarction (ACI).
methodsA total of 112 patients who have been diagnosed with ACI were enrolled in this study, and 112 healthy volunteers were served as the controls. The plasma of the patients and controls were collected, and total RNAs were isolated, and the expression levels of miR-99a, miR-99b, and miR-100 in the plasma of patients and controls were compared determined by RT-qPCR methods; moreover, the receiver operating characteristic (ROC) curve has been drawn to determine whether the plasma levels of miR-99b can distinguish patients with ACI from the controls; furthermore, the short-term prognosis of the patients was evaluated by glasgow outcome scale (GOS), and the correlation between the plasma levels of miR-99b and the GOS of the patients was evaluated. Finally, the correlation between the plasma level of miR-99 and VEGF of ACI patients was analyzed.
resultsIt was observed that miR-99b was significantly decreased in the plasma of ACI patients compared with the healthy controls (P < .01), while the plasma levels of miR-99a and miR-100 showed no significant differences between the patients with ACI and the healthy controls; moreover, the area under the curve (AUC) of miR-99b for the diagnosis of ACI was 0.8882 (95% confidence interval (CI), 0.8451-0.9313), suggesting that plasma level of miR-99b is a sensitive marker to distinguish patients with ACI from the healthy volunteers; furthermore, the serum level of miR-99b was negatively correlated with GOS score of the patients (r = -.56, P < .001); finally, the plasma level of miR-99b was negatively correlated with the levels of VEGF (r = -.3013, P = .0012).
conclusionmiR-99b was down-regulated in plasma of patients with ACI, and plasma level of miR-99b may be a potential diagnostic and prognostic marker for the diagnosis and treatment of ACI.
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