ArticleAACE clinical case reports
THYROID ACROPACHY: A RARE MANIFESTATION OF GRAVES DISEASE IN JOINTS.
Article in AACE clinical case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Nail Clubbing: A Dermatologic Window into Underlying Systemic Disease - an All of Us Study.Skin appendage disorders · 2025Article
- Graves' Eye Disease: Clinical and Radiological Diagnosis.Biomedicines · 2023Review
- A Complete Form of Pachydermoperiostosis Accompanied by a Pituitary Microadenoma.Clinical, cosmetic and investigational dermatology · 2023Article
- Clinical Imaging Features of Thyroid Acropachy.Internal medicine (Tokyo, Japan) · 2022Article
- Graves' disease.Nature reviews. Disease primers · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this report was to describe a patient with Graves acropachy, a rare manifestation of Graves disease (GD) that is clinically defined by skin tightness, digital clubbing, small-joint pain, and soft tissue edema progressing over months or years with gradual curving and enlargement of the fingers.
methodsThe patient was evaluated regarding thyroid function (serum free T4 [FT4] and thyroid-stimulating hormone [TSH] quantifications) and autoimmunity biomarkers (thyroid receptor antibody [TRAb]) as well as radiographic investigation of the extremities.
resultsA 52-year-old man presented with a history of thyrotoxicosis and clinical signs of Graves orbitopathy. Laboratory tests showed suppressed TSH (0.01 UI/L; normal, 0.4 to 4.5 UI/L) and elevated serum FT4 (7.77 ng/dL; normal, 0.93 to 1.7 ng/dL), with high TRAb levels (40 UI/L; normal, <1.75 UI/L). A diagnosis of thyrotoxicosis due to GD was made and the patient was treated with methimazole. After the patient complained of swelling in hands and feet, X-ray evaluation was conducted and established the thyroid acropachy.
conclusionWe present a case of a patient with GD associated with worsening extrathyroid manifestations during orbitopathy, dermopathy, and developed acropachy in hands and feet.
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Registered trials
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