ArticleInternational journal of clinical and experimental pathology2017
IFN-γ-induced microRNA-29b up-regulation contributes tokeratinocyte apoptosis in atopic dermatitis through inhibiting Bcl2L2.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- MicroRNAs in atopic dermatitis: A systematic review.Journal of cellular and molecular medicine · 2020Pooled it
- MicroRNAs in immune-related diseases: mechanism, functions and therapeutic perspectives.Frontiers in immunology · 2026Review
- miRNA-146-a, miRNA-21, miRNA-143, miRNA-29-b and miRNA-223 as Potential Biomarkers for Atopic Dermatitis.Clinics and practice · 2025Article
- The Role of MicroRNA in the Pathogenesis of Atopic Dermatitis.International journal of molecular sciences · 2025Review
- The role of microRNAs in atopic dermatitis.Non-coding RNA research · 2024Review
- Review
- Review
- Blood-Based Biomarkers for Eosinophilic Esophagitis and Concomitant Atopic Diseases: A Look into the Potential of Extracellular Vesicles.International journal of molecular sciences · 2023Review
- Anti-Inflammatory microRNAs for Treating Inflammatory Skin Diseases.Biomolecules · 2022Review
- IgG from Adult Atopic Dermatitis (AD) Patients Induces Thymic IL-22 Production and CLA Expression on CD4+ T Cells: Possible Epigenetic Implications Mediated by miRNA.International journal of molecular sciences · 2022Article
- Epigenetic Mechanisms of Epidermal Differentiation.International journal of molecular sciences · 2022Review
- Olfactomedin-4 improves cutaneous wound healing by promoting skin cell proliferation and migration through POU5F1/OCT4 and ESR1 signalling cascades.Cellular and molecular life sciences : CMLS · 2022Article
- Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence has suggested that microRNAs (miRNAs) may play a significant role in the pathogenesis of inflammatory skin conditions such as atopic dermatitis (AD). The aim of the present study was to evaluate the potential functions of miRNAs in AD and to identify the underlying mechanisms. We firstly analyzed miRNA expression in the skin lesions of patients with AD using microarray analysis. Validation analysis was performed in skin biopsy specimens and in serum using quantitative reverse transcription PCR (qRT-PCR). The relationship between microRNA-29b (miR-29b) and development of AD was further explored. Subsequently, gain- and loss-of-function studies were performed to determine the functions of miR-29b in interferon-γ (IFN-d)-induced keratinocytes (KCs) apoptosis. Further bioinformatics analysis and luciferase reporter assays were performed to predict its target genes, then the effects of miR-29b on the expression of BCL2-like2 (Bcl2L2) were investigated using qRT-PCR and western blot analysis. Finally, KCs were transfected with miR-29b mimics or Bcl2L2 siRNA (si-Bcl2L2) to explore the mechanism by which miR-29b plays in the pro-apoptotic roles in IFN-γ-treated keratinocytes. The miR-29b was found to be one of the most significantly up-regulated miRNAs in the skin lesions of patients with AD, as compared with healthy control and its expression was statistically associated with the development of AD. We, therefore, selected miR-29b as a candidate miRNA and investigated its function. Our
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Identifiers
31966903PMC6965990W3009015222What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.