ArticleInternational journal of clinical and experimental pathology2017
Differential susceptibility of mouse strains on pancreatic injury and regeneration in cerulein-induced pancreatitis.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Strain-specific responses to dextran sulfate sodium-induced ulcerative colitis in BALB/c and C57BL/6 mice: Comparative analysis of local versus extra-intestinal manifestations.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Strain-specific differences in cerulein-induced acute and recurrent acute murine pancreatitis.Scientific reports · 2025Article
- Relevance of Carcinogen-Induced Preclinical Cancer Models.Journal of xenobiotics · 2024Review
- Surfactant Protein D Dampens Lung Injury by Suppressing NLRP3 Inflammasome Activation and NF-κB Signaling in Acute Pancreatitis.Shock (Augusta, Ga.) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Acute pancreatitis (AP), a common disease, causes significant morbidity and mortality in clinical practice. Our objective of this study was to establish an experimental mouse AP model with cerulein treatment and to explore the susceptibility of mouse strains on the severity of pancreatic injury and the subsequent repair and regeneration. C57BL/6 and FVB/N mouse strains were used in this study. AP model was induced by six hourly intraperitoneal (i.p.) injections of cerulein dissolved in saline (100 μg/kg) administered on four consecutive days. Animals were sacrificed on 1, 3 and 7 days after last cerulein treatment, and then pancreas tissues were harvested and subjected to various histological, cellular and molecular analysis. Analyses of pancreatic injury and pancreatic amylase expression indicated that this cerulein-induced AP model was established successfully and that FVB/N mice showed more severe pancreatic injury and poor recovery compared to C57BL/6 strain. Analyses of myeloperoxidase (MPO), IL-1β and NF-κB showed that FVB/N strain exhibited more severe inflammation in the pancreas compared to C57BL/6 mice. Immunofluorescence analysis of activated caspase-3 and TUNEL assay indicated that the pancreas of FVB/N strain had more apoptosis compared to C57BL/6 mice. Analysis of Ki67 indicated FVB/N mice experienced more active proliferation compared to C57BL/6 strain. Collectively, these results demonstrated that there exists differential susceptibility on pancreatic injury and regeneration between FVB/N and C57BL/6 mice in the cerulein-induced AP.
Indexed as
Identifiers
31966883PMC6966007W3007854121What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.