ArticleInternational journal of clinical and experimental pathology2017
Infectious mononucleosis caused by EBV infection with clonal cytotoxic T cells in an infant patient.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- EBV-DNA viral load and lymphocyte subsets correlation in pediatric infectious mononucleosis with hepatic injury a retrospective cohort study.Frontiers in pediatrics · 2026Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infectious mononucleosis (IM) is a self-limiting lymphoproliferative disease usually caused by Epstein-Barr virus (EBV) infection, which predominantly infects B lymphocytes in adults. IM that occurs in T cells infected with EBV is rare and only a few cases have been reported worldwide. We describe a rare case of IM in an infant with an EBV infection predominantly in clonal cytotoxic T cells. A cervical node taken from a 10-month-old male infant was retrospectively analyzed. The architecture of the lymph node was effaced mostly with focal to extensive coagulative necrosis. In some areas, numerous infiltrating lymphocytes were detected, expressing CD2, CD3, and granzyme B, but lacked CD5 and CD56. EBV-encoded small RNAs were detected in the majority of lymphocytes. Furthermore, the T cell presented with T-cell receptor rearrangements. The patient did not do any radiation and chemotherapy. Thirty-two months follow up showed that the patient was well. We speculate IM can occur in infants through EBV infection of clonal cytotoxic T cells.
Indexed as
Identifiers
31966866PMC6965950W3009937090What OpenQuestion holds
Registered trials
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