Evidence map›Paper›PMID 31966857›Full record

ArticleInternational journal of clinical and experimental pathology2017

Methylenetetrahydrofolate reductase gene A1298C polymorphism and gene-environment interactions are associated with carotid plaque in a south Chinese population.

Feng Zhou, Nianzhen Wang, Lv Zhou, Yanhui Zhou, Tie Guo, Dan Yu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Feng ZhouDepartment of Neurology, Affiliated Haikou Hospital at Xiangya Medical College of Central South University Haikou, Hainan Province, China.
Nianzhen WangDepartment of Neurology, Affiliated Haikou Hospital at Xiangya Medical College of Central South University Haikou, Hainan Province, China.
Lv ZhouDepartment of Neurology, Affiliated Haikou Hospital at Xiangya Medical College of Central South University Haikou, Hainan Province, China.
Yanhui ZhouDepartment of Neurology, Affiliated Haikou Hospital at Xiangya Medical College of Central South University Haikou, Hainan Province, China.
Tie GuoDepartment of Neurology, Affiliated Haikou Hospital at Xiangya Medical College of Central South University Haikou, Hainan Province, China.
Dan YuDepartment of Neurology, Affiliated Haikou Hospital at Xiangya Medical College of Central South University Haikou, Hainan Province, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOur primary objective was to evaluate the associations of conventional risk factors and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with the risk of carotid plaque in a south Chinese population. Our secondary objective was to explore gene-environment interactions and potential relationship with carotid plaque.

methodWe enrolled 229 patients suffer from carotid plaque and 180 controls in this case-control study. We measured the carotid intima-media thickness by ultrasound and investigated conventional risk factors, biomarkers and C677T/A1298C MTHFR genotypes. Logistic analysis was used to evaluate the association between conventional risk factors and carotid plaque. The SNPstats platform was used to investigate the association between MTHFR gene polymorphisms and carotid plaque under 5 genetic models (dominant, recessive, codominant, over dominant and additive models). Gene-environment interactions analysis was then performed by multifactor dimensionality reduction.

resultsAge and hypertension were identified as independent risk factors of carotid plaque. C677T and A1298C demonstrated associations with carotid plaque under the recessive model (C677T:

conclusionMTHFR gene C677T and A1298C polymorphisms may act as modifiers of carotid plaque risk in south Chinese population. In addition, the combined effect of gene-environment interactions between A1298C polymorphism and conventional risk factors may promote the progression of carotid plaque.

Indexed as

A1298CC677Tcarotid plaquegene-environment interactionsMTHFR generisk factor

Identifiers

PMID31966857
PMCPMC6965971
OpenAlexW3027420173

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.