ArticleInternational journal of clinical and experimental pathology2017
Decreased microRNA-22 is associated with poor prognosis in cervical cancer.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- The pleiotropic roles of non-hormonal receptor basigin and regulatory microRNAs in breast cancer.NPJ breast cancer · 2025Review
- The therapeutic potential of exosomal miR-22 for cervical cancer radiotherapy.Cancer biology & therapy · 2020Article
- MicroRNA-22 enhances radiosensitivity in cervical cancer cell lines via direct inhibition of c-Myc binding protein, and the subsequent reduction in hTERT expression.Oncology letters · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cervical cancer is one of the most lethal gynecological malignancy. Aberrant expression of microRNAs (miRNAs) is associated with carcinogenesis of cervical cancer. The aim of current study was to elucidate the clinical significance of miR-22 in patients with cervical cancer. The expression levels of miR-22 in cervical intraepithelial neoplasia (CIN) and cervical cancer tissues as well as cervical cancer cell lines were quantified using real-time PCR. Then the potential prognostic value of the miR-22 was assessed. Our results showed that the expression level of miR-22 was significantly lower in cervical cancer tissues and cell lines. miR-22 levels were inversely correlated clinical stage both in CIN and cervical cancer. In addition, low expression of miR-22 was significantly associated with larger tumor size, presence of lymph node metastasis, and advanced tumor stage. Moreover, the patients expressing low levels of miR-22 had poorer five year overall survival and disease free survival. Multivariate analysis identified miR-22 as an independent prognostic factor for cervical cancer patients' overall survival. Taken together, we demonstrate that the miR-22 may serve as a novel therapeutic target and prognostic marker in patients with cervical cancer.
Indexed as
Identifiers
31966827PMC6965895W3026396652What OpenQuestion holds
Registered trials
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