ArticleInternational journal of clinical and experimental pathology2017
Prognostic significance of serum miR-193b in colorectal cancer.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- MiR-193b as an effective biomarker in human cancer prognosis for Asian patients: a meta-analysis.Translational cancer research · 2022Article
- Small Extracellular Vesicles: Key Forces Mediating the Development and Metastasis of Colorectal Cancer.Cells · 2022Review
- Exosomal miRNAs as a Promising Source of Biomarkers in Colorectal Cancer Progression.International journal of molecular sciences · 2022Review
- Blood Circulating Non-Coding RNAs for the Clinical Management of Triple-Negative Breast Cancer.Cancers · 2022Review
- Nanomaterial-Based Drug Delivery Systems: A New Weapon for Cancer Immunotherapy.International journal of nanomedicine · 2022Review
- Roles of exosomes in diagnosis and treatment of colorectal cancer.World journal of clinical cases · 2021Review
- Exosomal long noncoding RNAs and microRNAs in colorectal cancer.Tzu chi medical journalReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circulating microRNAs (miRNAs) have been demonstrated to be potential diagnostic and prognostic markers for many types of cancers including colorectal cancer (CRC). The aim of current study was to determine the clinical significance of serum miR-193b in CRC. The expression of serum miR-193b in CRC patients and healthy controls was detected by quantitative reverse transcription-polymerase chain reaction. Then the value of serum miR-193b as marker for CRC prognosis was evaluated. Our results showed that the expression levels of serum miR-193b were significantly reduced in CRC patients compared to healthy volunteers. Serum miR-193b discriminated CRC patients from healthy subjects with high accuracy. In addition, serum miR-193b levels were increased in CRC patients who received surgery treatment. Low serum miR-193b was associated with TNM stage, grade and lymph node metastasis. The overall/disease free survival time of patients with low serum miR-193b expression was significantly shorter compared to those with high serum miR-193b expression. Moreover, multivariate analysis showed that low serum miR-193b level predicted poor prognosis independently. These findings indicate that serum miR-193b serves as a promising novel prognostic biomarker for CRC.
Indexed as
Identifiers
31966826PMC6965940W3026236896What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.