ArticleInternational journal of clinical and experimental pathology2017
Inhibition of microRNA-155 alleviates lipopolysaccharide-induced kidney injury in mice.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- A crucial role of miR-155 in the pathomechanism of acute kidney injury.Frontiers in pharmacology · 2025Review
- Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury.Cell communication and signaling : CCS · 2024Article
- A mutual regulatory loop between miR-155 and SOCS1 influences renal inflammation and diabetic kidney disease.Molecular therapy. Nucleic acids · 2023Article
- Low‑dose ionizing radiation attenuates high glucose‑induced hepatic apoptosis and immune factor release via modulation of a miR‑155‑SOCS1 axis.Molecular medicine reports · 2023Article
- Microglia specific deletion of miR-155 in Alzheimer's disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures.Journal of neuroinflammation · 2023Article
- MicroRNAs in septic acute kidney injury.Burns & trauma · 2023Article
- Modes of action and diagnostic value of miRNAs in sepsis.Frontiers in immunology · 2022Review
- Non-Coding RNAs in Sepsis-Associated Acute Kidney Injury.Frontiers in physiology · 2022Review
- MicroRNA-155: Regulation of Immune Cells in Sepsis.Mediators of inflammation · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Accumulated evidences suggest that microRNAs (miRNAs) are related with inflammation-associated diseases.The aim of this study is to investigate whether miR-155 is involved in lipopolysaccharide (LPS)-induced kidney injury, and to explore the underlying mechanisms. Mice were intraperitoneally injected with LPS to construct endotoxemia mice model, and miR-155 inhibitor was injected via tail vein to suppress the expression of miR-155 in kidney. The results indicated that the expression of miR-155 was markedly increased in renal tissues of LPS-treated mice. And miR-155 inhibitor protected mice from LPS-induced kidney injury associated with the lower levels of TNF-α and IL-6 in renal tissues. Furthermore, inhibition of miR-155 increased the expression of suppressor of cytokine signaling 1 (SOCS1), a target gene of miR-155 and a negative regulator of Janus activated kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway. Consistently, inhibition of miR-155 suppressed the expression of JAK2, STAT3 and phosphorylated STAT3 (p-STAT3). All these results indicated that inhibition of miR-155 protects mice from LPS-induced kidney injury possibly through regulating SOCS1-JAK2/STAT signaling pathway, which suggested that miR-155 might be an important and potential target in developing therapy for preventing sepsis-associated kidney injury.
Indexed as
Identifiers
31966808PMC6965969W3004327656What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.