Evidence map›Paper›PMID 31966805›Full record

ArticleInternational journal of clinical and experimental pathology2017

Enhancement of neural regeneration after spinal cord injury using muscle graft in experimental dogs.

Mohamed M Refaat, Maha Baligh Zickri, Amal Elham Fares, Hala Gabr, Shaimaa Ibrahim El-Jaafary, Bassem Essam Mahmoud, Mostafa Abdallah Madbouly, Mohamed Abdelfadel Abdelfadel, Ali Mohamed Hammad, Haithem Am Farghali

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In one paragraph

Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 73% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mohamed M RefaatDepartment of Neurosurgery, Faculty of Medicine, Benisuef University Egypt.
Maha Baligh ZickriDepartment of Medical Histology and Cell Biology, Faculty of Medicine, Cairo University Egypt.
Amal Elham FaresDepartment of Medical Histology and Cell Biology, Faculty of Medicine, Cairo University Egypt.
Hala GabrDepartment of Clinical Pathology, Faculty of Medicine, Cairo University Egypt.
Shaimaa Ibrahim El-JaafaryDepartment of Neurology, Faculty of Medicine, Cairo University Egypt.
Bassem Essam MahmoudFaculty of Medicine, Cairo University Egypt.
Mostafa Abdallah MadboulyFaculty of Medicine, Cairo University Egypt.
Mohamed Abdelfadel AbdelfadelFaculty of Medicine, Cairo University Egypt.
Ali Mohamed HammadFaculty of Medicine, Cairo University Egypt.
Haithem Am FarghaliSurgery, Anesthesiology and Radiology Department, Faculty of Veterinary Medicine, Cairo University Egypt.
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsSpinal cord injuries (SCIs) can cause severe disability or death. The principal treatments for traumatic SCI include surgical stabilization and decompression. Using muscle as a scaffold is a new approach. The aim of this work is to evaluate the clinical efficacy of muscle graft as a scaffold for the growing axons organizing their growth, preventing gliosis in the damaged area and enhancing neural recovery in canine model of traumatic spinal cord injury.

methods14 dogs were divided into group I (Control group) 4 control dogs subjected to Sham operation, group II (Trauma control group) 5 dogs subjected to dorsal laminectomy with excision of 1 cm segment of the spinal cord and group III (Muscle graft group) 5 dogs subjected to dorsal laminectomy then muscle graft was taken from the longissimus thoraces and inserted into the spinal cord gap. The animals of all groups were euthanatized after 8 weeks. Olby and modified Tarlov scores were used to clinically evaluate the therapeutic effects. Spinal cord specimens were subjected to histological, morphometric and statistical studies.

resultsOlby and modified Tarlov scores revealed significant clinical improvement in the muscle graft group. Histological sections showed overgrowth of axons on the muscle graft and the sections started to organize as central gray matter and peripheral white matter. CD44 & CD105 stains were positive for endogenous stem cells.

conclusionsThis study proved the clinical efficacy of muscle grafting as a tool for induction of neuroregeneration after traumatic spinal cord injury.

Indexed as

dorsal laminectomymuscle graftSpinal cordstem cells

Identifiers

PMID31966805
PMCPMC6965910
OpenAlexW2904965642

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.