ArticleInternational journal of clinical and experimental pathology2017
Effects of soy isoflavones on testosterone synthetase in diet-induced obesity male rats.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Attenuation of carbon tetrachloride-induced male reproductive damage in albino laboratory rats using varying concentrations of supplemented soybean.Open veterinary journal · 2026Article
- Protective Effect of Soybean Isoflavone (SI) on Testicular Damages Induced by Zinc Oxide Nanoparticles (ZnONPs) in Male Mice.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Role of soy isoflavone in preventing aging changes in rat testis: Biochemical and histological studies.Saudi journal of biological sciences · 2022Article
- Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a complex metabolic disease, which causes serious impairment to the health of people. This study aimed to determine the influence of different-doses of soy isoflavones (SIF) on testicular morphology, testosterone levels and the expression of genes and proteins related to testosterone synthesis in diet-induced obesity (DIO) male rats. We used high-fat diet (HFD) to establish a DIO male rat model, then obese rats orally received SIF at doses of 0, 50, 250 and 500 mg/kg per day for four weeks. Results revealed that the body weight was obviously increased, and seminiferous tubules were significantly deformed in obese rats compared with that in normal diet fed controls. After SIF treatment, DIO male rats exhibited decreased body weight in a dose-dependent manner, accompanied with significantly alleviated testicular damages, as well as increased testosterone levels and steroidogenic acute regulatory (StAR), cytochrome P450 11A1 (CYP11A1), cytochrome P450 17A1 (CYP17), hydroxysteroid dehydrogenase-3β (HSD3β), and hydroxysteroid dehydrogenase-17β (HSD17β) protein and mRNA levels. In conclusion, SIF could alleviate testicular damages, increase testosterone levels, and upregulate the expression of proteins and genes related to testosterone synthesis in DIO male rats, which would be important for obesity male reproduction treatment.
Indexed as
Identifiers
31966792PMC6965929W3021253790What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.