The inhibition of microRNA-31 weakens acute spinal cord injury through nuclear factor-κB and TGF-β/Smad 2 in rat.

Weiping Sha, Xingxiang Zhang, Zhiping Zhou, Kelun Zhang

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In one paragraph

Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 69% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Weiping ShaDepartment of Orthopedic Surgery, Zhangjiagang First People's Hospital, Soochow University Zhangjiagang 215600, Jiangsu, China.

Xingxiang ZhangDepartment of Orthopedic Surgery, Zhangjiagang First People's Hospital, Soochow University Zhangjiagang 215600, Jiangsu, China.

Zhiping ZhouDepartment of Orthopedic Surgery, Zhangjiagang First People's Hospital, Soochow University Zhangjiagang 215600, Jiangsu, China.

Kelun ZhangDepartment of Orthopedic Surgery, Zhangjiagang First People's Hospital, Soochow University Zhangjiagang 215600, Jiangsu, China.

Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therefore, the aim of the present study is to evaluate that the therapeutic potential of microRNA-31 after spinal cord injury (SCI) in rats and to expound the potential neuroprotective mechanisms. In SCI model, microRNA-31 expression was up-regulated, compared with negative group. In vitro model, over-expression of microRNA-31 increases cell apoptosis and inflammation, compared with negative control group. Over-expression of microRNA-31 induced nuclear factor-κB (NF-κB), TGF-β and p-Smad 2 protein expression in vitro model of SCI, compared with negative control group. NF-κB inhibitor suppressed the effects of microRNA-31 on inflammation of vitro model of SCI. Meanwhile, TGF-β inhibitor suppressed the effects of microRNA-31 on apoptosis of in vitro model of SCI. The results clearly show that anti-microRNA-31 weakens inflammation and apoptosis by NF-κB and TGF-β/Smad 2 pathway in SCI.

Indexed as

apoptosisinflammationMicroRNA-31NF-κBspinal cord injuryTGF-β/Smad 2

Identifiers

PMID31966785

PMCPMC6965915

OpenAlexW3028415592

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.