ArticleInternational journal of clinical and experimental pathology2017
High expression of LAMP1 as a prognostic marker in patients with epithelial ovarian cancer.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Ultrasmall oral Saccharibacteria modulate gingival immunoactivation through type IV pili and TLR2-dependent endocytosis.Nature communications · 2026Article
- Tumor-associated macrophages display differential protein cargo sorting in extracellular vesicles associated with poor survival in ovarian cancer.Molecular medicine (Cambridge, Mass.) · 2026Article
- LAMP1 as a Target for PET Imaging in Adenocarcinoma Xenograft Models.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Genetically encoded and modular subcellular organelle probes reveal dysfunction in lysosomes and mitochondria driven by PRKN knockout.iScience · 2025Article
- Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven bybioRxiv : the preprint server for biology · 2025Article
- Review
- Development of a prognostic model based on lysosome-related genes for ovarian cancer: insights into tumor microenvironment, mutation patterns, and personalized treatment strategies.Cancer cell international · 2024Article
- Research Progress on the Mechanism of Lysosome in Myocardial Ischemia-Reperfusion Injury Based on Autophagy.Reviews in cardiovascular medicine · 2024Review
- Research on the effect of LAMP1 in the development and progression of ccRCC and its potential mechanism with LC3C-mediated autophagy.Frontiers in immunology · 2024Article
- Design, synthesis, and biological evaluation of tetrahydroquinolinones and tetrahydroquinolines with anticancer activity.Scientific reports · 2022Article
- Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer.Cancer research communications · 2022Article
- KLHL14: A Novel Prognostic Biomarker and Therapeutic Target for Ovarian Cancer.Journal of oncology · 2022Article
- Overexpression of Lysosome-Associated Membrane Protein 1 in Oral Squamous Cell Carcinoma and its Correlation with Tumor Differentiation and Metastasis.Iranian journal of otorhinolaryngology · 2022Article
- Review
- Deciphering the Role of CaCancers · 2021Review
- Autophagy-Related Signature for Head and Neck Squamous Cell Carcinoma.Disease markers · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lysosome Associated Membrane Protein-1 (LAMP1), expressed in several functional processes, is a heavily glycosylated lysosomal membrane protein which is able to protect the lysosomal membranes from intracellular proteolysis. Its pro-tumorigenic effects are involved in the development of several types of Malignancy. However, the role of LAMP1 in human Epithelial Ovarian Cancer (EOC) patients remains unclear. To demonstrate its prognostic significance in EOC, the methods of RT-PCR and IHC were used to evaluate LAMP1 expression in both EOC and nonmalignant tissues. What's more, the relationship between LAMP1 and clinicopathological factors was investigated. Survival analysis was used to elaborate its prognostic value. Expression of LAMP1 in tumor cells in EOC was significantly higher than those in noncancerous tissues. LAMP1 over-expression in EOC was significantly related to FIGO stage, metastasis invasion, positive ascites cell and the level of serum CA125. The Kaplan-Meier plot and Cox regression method have shown that LAMP1 over-expression in EOC and FIGO stage was significantly related to malignant features in EOC and EOC patients' unfavorable survival. It was strongly evidenced in our research that LAMP1 is a prognostic factor in EOC. Our results suggest that LAMP1 could be used as a poor prognostic factor and novel therapeutic target for EOC.
Indexed as
Identifiers
31966783PMC6965383W3026383712What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.