ArticleInternational journal of clinical and experimental pathology2017
Lichen extracts regulate the expression of BMP7 via miR-194-5p targeting to decrease the risk atrial fibrillation.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAtrial fibrillation (AF), the most common cardiac supraventricular arrhythmia, affects more than 5 million people worldwide. Increasing evidence has demonstrated that genetic factors play an important role in the pathogenesis of AF, and multiple genes responsible for AF have been identified. A better understanding of the genetic mechanism underlying AF would be expected to lead to more accurate risk stratification of AF and optimal clinical treatment strategies.
methodsImmunofluorescence staining was performed to find the components which would have effects on the H9c2 cells development. The changes of BMP7 and miR-194-5p expressions were detected before and after Human Cardiac Myocytes (HCM) were treated with Lichen extraction. In order to confirm whether Lichen could increase the expression of BMP7 through inhibiting the expression of miR-194-5p, the mRNA levels of BMP7 and miR-194-5p were determined in HCM before and after the treatment of Lichen on the conditions that miR-194-5p was over-expressed or not.
resultsAfter 48 hours' treatment with 20 µg/mL Lichen extracts, the Collagen I expression level significantly decreased. The expressions of several genes in H9c2 cells could were changed after the treatment of Lichen extracts and some mRNA of them could also be targeted by miR-194-5p including BMP7. Lichen could depress the expression of miR-194-5p in HCM no matter miR-194-5p was overexpressed or not and correspondingly, the expression of BMP7 could be increased in both conditions.
conclusionsIt is indicated that Lichen extracts could regulate the expression of atrial fibrillation-associated genes via miR-194-5a targeting.
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31966782PMC6965457W3004262462What OpenQuestion holds
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