ArticleInternational journal of clinical and experimental pathology2017
Effects of icariin on osteogenic differentiation of bone marrow stromal cells in beagle canine.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Potential role of natural products in veterinary stem cell therapy.Stem cell research & therapy · 2026Review
- Calcium phosphate cement with icariin-loaded gelatin microspheres as a local drug delivery system for bone regeneration.Biomedical engineering online · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Icariin (ICA), as the main active component in perennial herb Epimedium, displays a wide range of pharmacological and biological effects, including enhanced sexual function, immune regulation, anti-inflammatory, and anti-osteoporosis. In this study, the effect of ICA on osteogenic differentiation of bone marrow derived stromal cells (BMSCs) from a Beagle dog was assessed. BMSCs were Isolated from the canine bone marrow, cultured and identified by applying morphology and multi-lineage differentiation assays. Cell counting kit-8 (CCK-8) assay showed that ICA significantly promoted BMSC proliferation in a dose-dependent manner. Alkaline phosphatase (ALP) activity assay showed that ICA can increase ALP activity in a dose-dependent manner. Furthermore, RT-PCR and Western-blot indicated that ICA upregulated osteogenic-related genes and proteins. Alizarin red staining demonstrated the induced calcium deposition in BMSCs treated with 10
Indexed as
Identifiers
31966765PMC6965438W3028185344What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.