ArticleInternational journal of clinical and experimental pathology2017
Roles of IL-4 genetic polymorphisms and haplotypes in the risk of gastric cancer and their interaction with environmental factors.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Role of Interleukins and New Perspectives in Mechanisms of Resistance to Chemotherapy in Gastric Cancer.Biomedicines · 2022Review
- Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer.International journal of molecular sciences · 2021Review
- Contribution of Interleukin-4 Promoter Genotypes to Gastric Cancer Risk in Taiwan.In vivo (Athens, Greece)Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer (GC) is the fifth most common cancer and imposes a global cancer burden. IL-4 is a typical cytokine of Th2 cells. IL-4 genetic polymorphisms have multiple functions in many cancers. We performed a case-control study in the Chinese population, and evaluated the association between rs2243250 (590 C/T), rs2227284 (107 T/C), rs2070874 (166 T/C) and rs1801275 (576 Q/R) and gastric cancer risk. A total of 340 gastric cancer patients and 364 controls were enrolled into our study. SNP genotyping of IL-4 rs2243250, rs2227284, rs2070874 and rs1801275 was done in a 384-well plate format on the sequenom MassARRAY platform (Sequenom, San Diego, USA). We observed the CC genotype of IL-4 rs2243250 was associated with risk of gastric cancer when compared with the TT genotype (OR=2.36, 95% CI=1.49-3.75). Moreover, individuals harboring the CT+CC genotype exposed a higher risk of gastric cancer in comparison with the TT genotype (OR=1.66, 95% CI=1.17-2.35). However, there was no significant association between IL-4 rs2227284, rs2070874 and rs1801275 and gastric cancer risk. The TT+CT genotype of IL-4 rs2243250 showed a significant increased risk of gastric cancer in males (OR=2.48, 95% CI=1.67-3.68) and those without a family history of cancer (OR=1.97, 95% CI=1.44-2.70). In ever drinkers (OR=2.04, 95% CI=1.24-3.37) and H. pylori infected patients (OR=2.31, 95% CI=1.38-3.86), the TT+CT genotype of IL-4 rs2243250 had a higher risk of gastric cancer than non-drinkers (OR=1.77, 95% CI=1.20-2.61) and non-H. pylori infected ones (OR=1.76, 95% CI=1.19-2.62). The CTCA (OR=1.54, 95% CI=1.06-2.24), CTCG (OR=1.83, 95% CI=1.16-2.86) and CTTG (OR=1.89, 95% CI=1.16-3.07) haplotypes showed an increased risk in gastric cancer, while the TCTG (OR=0.22, 95% CI=0.09-0.52), TTCG (OR=0.47, 95% CI=0.32-0.69) and TTTA (OR=0.58, 95% CI=0.42-30.79) haplotypes were associated with an reduction risk of gastric cancer. In conclusion, our study indicated that the IL-4 rs2243250 CC genotype and CT+CC genotype were associated with gastric cancer risk in the Chinese population, and IL-4 haplotypes plays an important role in the development of gastric cancer.
Indexed as
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31966763PMC6965378W3012297972What OpenQuestion holds
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