Evidence map›Paper›PMID 31966762›Full record

ArticleInternational journal of clinical and experimental pathology2017

Bmi-1 serves as a potential novel marker for progression in human cutaneous basal cell carcinoma.

Hongyan Zhu, Jian Wu, Xiaomei Cui, Xiaodong Chen

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 71% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hongyan ZhuDepartment of Dermatology, Suzhou Municipal Hospital Affiliated to Nanjing Medical University Suzhou, Jiangsu Province, China.
Jian WuDepartment of Dermatology, Suzhou Municipal Hospital Affiliated to Nanjing Medical University Suzhou, Jiangsu Province, China.
Xiaomei CuiDepartment of Dermatology and Venereology, Affiliated Hospital of Nantong University Nantong, Jiangsu Province, China.
Xiaodong ChenDepartment of Dermatology and Venereology, Affiliated Hospital of Nantong University Nantong, Jiangsu Province, China.
Nantong University · CNSuzhou Municipal Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) is one of the core members of the PRC1 complex (the polycomb gene family) involved in tumorigenesis. The aim of this study is to investigate the expression and possible function of Bmi-1 in cutaneous basal cell carcinoma (BCC). Here, by immunohistochemical staining, we found that elevated Bmi-1 expression was more commonly observed in fresh BCC tissues compared with normal. Bmi-1 RNAi revealed that suppression of endogenous Bmi-1 expression in A431 cells attenuated cell proliferation, invasion, and induced apoptosis of BCC cells. Indicating Bmi-1 may play an important role in progression of BCC and may serve as a novel marker for therapeutic targets.

Indexed as

apoptosisbasal cell carcinomaBMI-1invasionproliferation

Identifiers

PMID31966762
PMCPMC6965421
OpenAlexW3028047162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.